Validation of the Application of Solid Contact Ion-Selective Electrode for Off-Body Sweat Ion Monitoring
Abstract
1. Introduction
2. Materials and Methods
2.1. Reagents and Materials
2.2. Human Sweat Sampling and Storage
2.3. Sweat Samples Detection by the Designed Electrochemical Sensor
2.4. Sweat Sample Detection by ICP-OES
2.5. Data Analysis
3. Results and Discussion
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Kim, J.; Campbell, A.S.; de Ávila, B.E.-F.; Wang, J. Wearable biosensors for healthcare monitoring. Nat. Biotechnol. 2019, 37, 389–406. [Google Scholar] [CrossRef] [PubMed]
- Liu, H.; Yan, X.; Gu, Z.; Xiu, G.; Xiao, X. Electrochemical sensing in contact lenses. Electroanal. 2021, 34, 227–236. [Google Scholar] [CrossRef]
- Gao, W.; Emaminejad, S.; Nyein, H.Y.Y.; Challa, S.; Chen, K.; Peck, A.; Fahad, H.M.; Ota, H.; Shiraki, H.; Kiriya, D.; et al. Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis. Nature 2016, 529, 509–514. [Google Scholar] [CrossRef] [PubMed]
- Yang, Y.; Gao, W. Wearable and flexible electronics for continuous molecular monitoring. Chem. Soc. Rev. 2019, 48, 1465–1491. [Google Scholar] [CrossRef] [PubMed]
- Heikenfeld, J.; Jajack, A.; Feldman, B.; Granger, S.W.; Gaitonde, S.; Begtrup, G.; Katchman, B.A. Accessing analytes in biofluids for peripheral biochemical monitoring. Nat. Biotechnol. 2019, 37, 407–419. [Google Scholar] [CrossRef] [PubMed]
- Mena-Bravo, A.; Luque de Castro, M.D. Sweat: A sample with limited present applications and promising future in metabolomics. J. Pharm. Biomed. Anal. 2014, 90, 139–147. [Google Scholar] [CrossRef]
- LeGrys, V.; Moon, T.; Laux, J.; Accurso, F.; Martiniano, S. A multicenter evaluation of sweat chloride concentration and variation in infants with cystic fibrosis. J. Cyst. Fibros. 2019, 18, 190–193. [Google Scholar] [CrossRef]
- Ray, T.R.; Ivanovic, M.; Curtis, P.M.; Franklin, D.; Guventurk, K.; Jeang, W.J.; Chafetz, J.; Gaertner, H.; Young, G.; Rebollo, S.; et al. Soft, skin-interfaced sweat stickers for cystic fibrosis diagnosis and management. Sci. Transl. Med. 2021, 13, eabd8109. [Google Scholar] [CrossRef]
- Desax, M.C.; Ammann, R.A.; Hammer, J.; Schoeni, M.H.; Barben, J.; On behalf of the Swiss Paediatric Respiratory Research. Nanoduct® sweat testing for rapid diagnosis in newborns, infants and children with cystic fibrosis. Eur. J. Pediatr. 2008, 167, 299–304. [Google Scholar] [CrossRef]
- Bariya, M.; Nyein, H.Y.Y.; Javey, A. Wearable sweat sensors. Nat. Electron. 2018, 1, 160–171. [Google Scholar] [CrossRef]
- Hauke, A.; Simmers, P.; Ojha, Y.R.; Cameron, B.D.; Ballweg, R.; Zhang, T.; Twine, N.; Brothers, M.; Gomez, E.; Heikenfeld, J. Complete validation of a continuous and blood-correlated sweat biosensing device with integrated sweat stimulation. Lab Chip 2018, 18, 3750–3759. [Google Scholar] [CrossRef] [PubMed]
- Vairo, D.; Bruzzese, L.; Marlinge, M.; Fuster, L.; Adjriou, N.; Kipson, N.; Brunet, P.; Cautela, J.; Jammes, Y.; Mottola, G.; et al. Towards addressing the body electrolyte environment via sweat analysis: Pilocarpine iontophoresis supports assessment of plasma potassium concentration. Sci. Rep. 2017, 7, 11801. [Google Scholar] [CrossRef] [PubMed]
- Wiorek, A.; Parrilla, M.; Cuartero, M.; Crespo, G.A. Epidermal patch with glucose biosensor: pH and temperature correction toward more accurate sweat analysis during sport practice. Anal. Chem. 2020, 92, 10153–10161. [Google Scholar] [CrossRef] [PubMed]
- Cuartero, M.; Parrilla, M.; Crespo, G.A. Wearable potentiometric sensors for medical applications. Sensors 2019, 19, 363. [Google Scholar] [CrossRef] [PubMed]
- Hu, J.; Stein, A.; Bühlmann, P. Rational design of all-solid-state ion-selective electrodes and reference electrodes. TrAC Trends Anal. Chem. 2016, 76, 102–114. [Google Scholar] [CrossRef]
- Parrilla, M.; Cuartero, M.; Crespo, G.A. Wearable potentiometric ion sensors. TrAC Trends Anal. Chem. 2019, 110, 303–320. [Google Scholar] [CrossRef]
- Bakker, E. Enhancing ion-selective polymeric membrane electrodes by instrumental control. TrAC Trends Anal. Chem. 2014, 53, 98–105. [Google Scholar] [CrossRef]
- He, X.; Yang, S.; Pei, Q.; Song, Y.; Liu, C.; Xu, T.; Zhang, X. Integrated smart Janus textile bands for self-pumping sweat sampling and Analysis. ACS Sensors 2020, 5, 1548–1554. [Google Scholar] [CrossRef]
- Xu, G.; Cheng, C.; Liu, Z.; Yuan, W.; Wu, X.; Lu, Y.; Low, S.S.; Liu, J.; Zhu, L.; Ji, D.; et al. Battery-free and wireless epidermal electro-chemical system with all-printed stretchable electrode array for multiplexed in situ sweat analysis. Adv. Mater. Technol. 2019, 4, 1800658. [Google Scholar] [CrossRef]
- Pirovano, P.; Dorrian, M.; Shinde, A.; Donohoe, A.; Brady, A.J.; Moyna, N.M.; Wallace, G.; Diamond, D.; McCaul, M. A wearable sensor for the detection of sodium and potassium in human sweat during exercise. Talanta 2020, 219, 121145. [Google Scholar] [CrossRef]
- He, W.; Wang, C.; Wang, H.; Jian, M.; Lu, W.; Liang, X.; Zhang, X.; Yang, F.; Zhang, Y. Integrated textile sensor patch for real-time and multiplex sweat analysis. Sci. Adv. 2019, 5, eaax0649. [Google Scholar] [CrossRef] [PubMed]
- Cazalé, A.; Sant, W.; Ginot, F.; Launay, J.-C.; Savourey, G.; Revol-Cavalier, F.; Lagarde, J.; Heinry, D.; Temple-Boyer, P. Physiological stress monitoring using sodium ion potentiometric microsensors for sweat analysis. Sensors Actuators B Chem. 2016, 225, 1–9. [Google Scholar] [CrossRef]
- Parrilla, M.; Ortiz-Gómez, I.; Cánovas, R.; Salinas-Castillo, A.; Cuartero, M.; Crespo, G.A. Wearable potentiometric ion patch for on-body electrolyte monitoring in sweat: Toward a validation strategy to ensure physiological relevance. Anal. Chem. 2019, 91, 8644–8651. [Google Scholar] [CrossRef]
- Liu, H.; Gu, Z.; Zhao, Q.; Li, S.; Ding, X.; Xiao, X.; Xiu, G. Printed circuit board integrated wearable ion-selective electrode with potential treatment for highly repeatable sweat monitoring. Sensors Actuators B Chem. 2022, 355, 131102. [Google Scholar] [CrossRef]
- Nyein, H.Y.Y.; Gao, W.; Shahpar, Z.; Emaminejad, S.; Challa, S.; Chen, K.; Fahad, H.M.; Tai, L.-C.; Ota, H.; Davis, R.W.; et al. A wearable electrochemical platform for noninvasive simultaneous monitoring of Ca2+ and pH. ACS Nano 2016, 10, 7216–7224. [Google Scholar] [CrossRef]
- Appenzeller, B.M.; Schummer, C.; Rodrigues, S.B.; Wennig, R. Determination of the volume of sweat accumulated in a sweat-patch using sodium and potassium as internal reference. J. Chromatogr. B 2007, 852, 333–337. [Google Scholar] [CrossRef]
- Patterson, M.J.; Galloway, S.D.; Nimmo, M.A. Variations in regional sweat composition in normal human males. Exp. Physiol. 2000, 85, 869–875. [Google Scholar] [CrossRef]
- Heinemann, L.; Schoemaker, M.; Schmelzeisen-Redecker, G.; Hinzmann, R.; Kassab, A.; Freckmann, G.; Reiterer, F.; Del Re, L. Benefits and Limitations of MARD as a performance parameter for continuous glucose monitoring in the interstitial space. J. Diabetes Sci. Technol. 2019, 14, 135–150. [Google Scholar] [CrossRef]
- Schrangl, P.; Reiterer, F.; Heinemann, L.; Freckmann, G.; Del Re, L. Limits to the evaluation of the accuracy of continuous glucose monitoring systems by clinical trials. Biosensors 2018, 8, 50. [Google Scholar] [CrossRef]
- Buono, M.J.; Ball, K.D.; Kolkhorst, F.W. Sodium ion concentration vs. sweat rate relationship in humans. J. Appl. Physiol. 2007, 103, 990–994. [Google Scholar] [CrossRef]
- Shirreffs, S.M.; Aragon-Vargas, L.F.; Chamorro, M.; Maughan, R.J.; Serratosa, L.; Zachwieja, J.J. The sweating response of elite professional soccer players to training in the heat. Int. J. Sports Med. 2005, 26, 90–95. [Google Scholar] [CrossRef] [PubMed]
- Nuttall, F.Q. Body mass index: Obesity, BMI, and health: A critical review. Nutr. Today 2015, 50, 117. [Google Scholar] [CrossRef] [PubMed]
- WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 2004, 363, 157–163. [Google Scholar] [CrossRef]
- Osayande, O.E.; Ogbonmwan, E.E.; Ugwu, A.C. Sweat rate and electrolyte composition in young women of varying body mass indices during moderate exercise. J. Biosci. Med. 2016, 04, 14–22. [Google Scholar] [CrossRef][Green Version]
- Liu, C.; Xu, T.; Wang, D.; Zhang, X. The role of sampling in wearable sweat sensors. Talanta 2020, 212, 120801. [Google Scholar] [CrossRef]
- Hammond, K.B.; Turcios, N.L.; Gibson, L.E. Clinical evaluation of the macroduct sweat collection system and conductivity analyzer in the diagnosis of cystic fibrosis. J. Pediatr. 1994, 124, 255–260. [Google Scholar] [CrossRef]
- Baker, L.B. Sweating rate and sweat sodium concentration in athletes: A review of methodology and intra/interindividual variability. Sports Med. 2017, 47, 111–128. [Google Scholar] [CrossRef]
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Liu, H.; Gu, Z.; Liu, Y.; Xiao, X.; Xiu, G. Validation of the Application of Solid Contact Ion-Selective Electrode for Off-Body Sweat Ion Monitoring. Biosensors 2022, 12, 229. https://doi.org/10.3390/bios12040229
Liu H, Gu Z, Liu Y, Xiao X, Xiu G. Validation of the Application of Solid Contact Ion-Selective Electrode for Off-Body Sweat Ion Monitoring. Biosensors. 2022; 12(4):229. https://doi.org/10.3390/bios12040229
Chicago/Turabian StyleLiu, Huixin, Zhen Gu, Yuan Liu, Xinxin Xiao, and Guangli Xiu. 2022. "Validation of the Application of Solid Contact Ion-Selective Electrode for Off-Body Sweat Ion Monitoring" Biosensors 12, no. 4: 229. https://doi.org/10.3390/bios12040229
APA StyleLiu, H., Gu, Z., Liu, Y., Xiao, X., & Xiu, G. (2022). Validation of the Application of Solid Contact Ion-Selective Electrode for Off-Body Sweat Ion Monitoring. Biosensors, 12(4), 229. https://doi.org/10.3390/bios12040229