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The Spectroscopic Properties and Microscopic Imaging of Thulium-Doped Upconversion Nanoparticles Excited at Different NIR-II Light

1
Centre for Optical and Electromagnetic Research, Guangdong Provincial Key Laboratory of Optical Information Materials and Technology, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, China
2
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
3
MOE & Guangdong Provincial Key Laboratory of Laser Life Science, Guangzhou Key Laboratory of Spectral Analysis and Functional Probes, College of Biophotonics, South China Normal University, Guangzhou 510006, China
4
Experimental Biomolecular Physics, Department of Applied Physics, Royal Institute of Technology (KTH), SE-106 91 Stockholm, Sweden
5
National Centre for International Research on Green Optoelectronics, South China Normal University, Guangzhou 510006, China
*
Author to whom correspondence should be addressed.
Biosensors 2021, 11(5), 148; https://doi.org/10.3390/bios11050148
Received: 23 March 2021 / Revised: 20 April 2021 / Accepted: 22 April 2021 / Published: 10 May 2021
Lanthanide-doped upconversion nanoparticles (UCNPs) are promising bioimaging nanoprobes due to their excellent photostability. As one of the most commonly used lanthanide activators, Tm3+ ions have perfect ladder-type electron configuration and can be directly excited by bio-friendly near-infrared-II (NIR-II) wavelengths. Here, the emission characteristics of Tm3+-doped nanoparticles under laser excitations of different near-infrared-II wavelengths were systematically investigated. The 1064 nm, 1150 nm, and 1208 nm lasers are proposed to be three excitation strategies with different response spectra of Tm3+ ions. In particular, we found that 1150 nm laser excitation enables intense three-photon 475 nm emission, which is nearly 100 times stronger than that excited by 1064 nm excitation. We further optimized the luminescence brightness after investigating the luminescence quenching mechanism of bare NaYF4: Tm (1.75%) core. After growing an inert shell, a ten-fold increase of emission intensity was achieved. Combining the advantages of NIR-II wavelength and the higher-order nonlinear excitation, a promising facile excitation strategy was developed for the application of thulium-doped upconversion nanoparticles in nanoparticles imaging and cancer cell microscopic imaging. View Full-Text
Keywords: upconversion nanoparticles; near-infrared-II; excitation mechanisms; luminescence quenching; microscopic imaging upconversion nanoparticles; near-infrared-II; excitation mechanisms; luminescence quenching; microscopic imaging
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MDPI and ACS Style

Peng, T.; Pu, R.; Wang, B.; Zhu, Z.; Liu, K.; Wang, F.; Wei, W.; Liu, H.; Zhan, Q. The Spectroscopic Properties and Microscopic Imaging of Thulium-Doped Upconversion Nanoparticles Excited at Different NIR-II Light. Biosensors 2021, 11, 148. https://doi.org/10.3390/bios11050148

AMA Style

Peng T, Pu R, Wang B, Zhu Z, Liu K, Wang F, Wei W, Liu H, Zhan Q. The Spectroscopic Properties and Microscopic Imaging of Thulium-Doped Upconversion Nanoparticles Excited at Different NIR-II Light. Biosensors. 2021; 11(5):148. https://doi.org/10.3390/bios11050148

Chicago/Turabian Style

Peng, Tingting, Rui Pu, Baoju Wang, Zhimin Zhu, Kai Liu, Fan Wang, Wei Wei, Haichun Liu, and Qiuqiang Zhan. 2021. "The Spectroscopic Properties and Microscopic Imaging of Thulium-Doped Upconversion Nanoparticles Excited at Different NIR-II Light" Biosensors 11, no. 5: 148. https://doi.org/10.3390/bios11050148

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