Next Article in Journal
Immobilization Techniques for Aptamers on Gold Electrodes for the Electrochemical Detection of Proteins: A Review
Previous Article in Journal
Development of Novel Magneto-Biosensor for Sulfapyridine Detection
Open AccessCommunication

Host-Modulation Therapy and Chair-Side Diagnostics in the Treatment of Peri-Implantitis

1
Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, PO Box 63 (Haartmaninkatu 8) FI-00014 Helsinki, Finland
2
Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden
*
Authors to whom correspondence should be addressed.
Biosensors 2020, 10(5), 44; https://doi.org/10.3390/bios10050044
Received: 20 March 2020 / Revised: 22 April 2020 / Accepted: 24 April 2020 / Published: 25 April 2020
(This article belongs to the Section Biosensors and Healthcare)
Previous studies report periodontitis and peri-implantitis being able to induce systemic low-grade inflammation, which is known to be associated with increased risk for some systemic medical disease such as cardiovascular disease. In this regard, recent studies have shown that host modulation therapy (HMT) together with traditional mechanical and surgical treatment not only cease the progression of periodontitis but also reduce the systemic collagenolytic biomarkers in both oral fluids and circulation. This suggests that the corresponding adjunctive HMT-medication could be effective in the prevention and treatment of dental peri-implantitis, as well. Furthermore, low-cost, safe, and practical oral fluid active matrix metalloproteinase-8 (aMMP-8) lateral-flow immunotests have been proposed as point-of-care/chair-side diagnostic tools to detect peri-implantitis and periodontitis, and to monitor their effective resolutions, while using various therapeutic strategies, including host modulation. This study reports the potential benefits of HMT-medication in the prevention and treatment of dental peri-implantitis among five patients (four of five were current/ex-smokers). In addition, the aMMP-8 point-of-care test diagnosed 20 peri-implantitis and 20 healthy controls correctly. In conclusion, this study and previous studies support the potential effectiveness of HMT-medication(s) and point-of-care/chair-side technologies in the treatment and diagnostics/monitoring of peri-implantitis. However, more studies are needed to further confirm this. View Full-Text
Keywords: peri-implantitis; periodontitis; doxycycline; inflammation; matrix metalloproteinase 8; point-of-care testing; treatment outcome peri-implantitis; periodontitis; doxycycline; inflammation; matrix metalloproteinase 8; point-of-care testing; treatment outcome
Show Figures

Figure 1

MDPI and ACS Style

Sorsa, T.; Bacigalupo, J.; Könönen, M.; Pärnänen, P.; Räisänen, I.T. Host-Modulation Therapy and Chair-Side Diagnostics in the Treatment of Peri-Implantitis. Biosensors 2020, 10, 44.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop