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Open AccessCommunication

Design and Fabrication of Capillary-Driven Flow Device for Point-Of-Care Diagnostics

by Sammer-ul Hassan 1,2,* and Xunli Zhang 1,2,*
1
Bioengineering Research Group, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton SO17 1BJ, UK
2
Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK
*
Authors to whom correspondence should be addressed.
Biosensors 2020, 10(4), 39; https://doi.org/10.3390/bios10040039
Received: 26 March 2020 / Revised: 9 April 2020 / Accepted: 13 April 2020 / Published: 15 April 2020
(This article belongs to the Special Issue Optical Diagnostics with Point-of-Care and Point-of-Need Applications)
Point-of-care (POC) diagnostics enables the diagnosis and monitoring of patients from the clinic or their home. Ideally, POC devices should be compact, portable and operatable without the requirement of expertise or complex fluid mechanical controls. This paper showcases a chip-and-dip device, which works on the principle of capillary-driven flow microfluidics and allows analytes’ detection by multiple microchannels in a single microchip via smartphone imaging. The chip-and-dip device, fabricated with inexpensive materials, works by simply dipping the reagents-coated microchip consisting of microchannels into a fluidic sample. The sample is loaded into the microchannels via capillary action and reacts with the reagents to produce a colourimetric signal. Unlike dipstick tests, this device allows the loading of bacterial/pathogenic samples for antimicrobial testing. A single device can be coated with multiple reagents, and more analytes can be detected in one sample. This platform could be used for a wide variety of assays. Here, we show the design, fabrication and working principle of the chip-and-dip flow device along with a specific application consisting in the determination of β-lactamase activity and cortisol. The simplicity, robustness and multiplexing capability of the chip-and-dip device will allow it to be used for POC diagnostics. View Full-Text
Keywords: microfluidics; point-of-care (POC) diagnostics; β-lactamase; lab-on-a-chip; capillary-driven flow; colorimetry; optical detections; smartphone imaging; analytical chemistry microfluidics; point-of-care (POC) diagnostics; β-lactamase; lab-on-a-chip; capillary-driven flow; colorimetry; optical detections; smartphone imaging; analytical chemistry
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Hassan, S.-U.; Zhang, X. Design and Fabrication of Capillary-Driven Flow Device for Point-Of-Care Diagnostics. Biosensors 2020, 10, 39.

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