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Nanomaterials 2019, 9(2), 236; https://doi.org/10.3390/nano9020236

Biocellulose for Incisional Hernia Repair—An Experimental Pilot Study

1
Department of General, Visceral and Vascular Surgery, Jena University Hospital, 07747 Jena, Germany
2
Experimental Transplantation Surgery, Department of General, Visceral and Vascular Surgery, Jena University Hospital, 07747 Jena, Germany
3
Institute of Pathology Hospital of Chemnitz, 09116 Chemnitz, Germany
4
Department of General and Visceral Surgery, St. Vinzenz Hospital, 33098 Paderborn, Germany
*
Author to whom correspondence should be addressed.
Received: 14 December 2018 / Revised: 31 January 2019 / Accepted: 7 February 2019 / Published: 10 February 2019
(This article belongs to the Special Issue Cellulose Nanomaterials)
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Abstract

Ventral or incisional hernia are a common disease pattern in general surgery. Most commonly, a mesh repair is used for reconstruction, whereby the mesh itself might cause complications, like infections or adhesions. Biological materials, like biocellulose, might reduce these clinical problems substantially. In this prospective rodent study, a biocellulose mesh (produced by Gluconacetobacter xylinus) was implanted either by a sublay technique or as supplementation of the abdominal wall. After an observation period of 90 days, animals were sacrificed. The adhesions after the reconstruction of the abdominal wall were moderate. The histologic investigations revealed that the biocellulose itself was inert, with a minimal regenerative response surrounding the mesh. The explanted mesh showed a minimal shrinkage (around 15%) as well as a minimal loss of tear-out force, which might be without clinical relevance. This is the first in vivo study describing biocellulose as a suitable mesh for the repair of ventral hernia in two different hernia models. The material seems to be a promising option for solving actual problems in modern hernia surgery. View Full-Text
Keywords: mesh; mesh infection; abdominal wall; reconstruction mesh; mesh infection; abdominal wall; reconstruction
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Rauchfuß, F.; Helble, J.; Bruns, J.; Dirsch, O.; Dahmen, U.; Ardelt, M.; Settmacher, U.; Scheuerlein, H. Biocellulose for Incisional Hernia Repair—An Experimental Pilot Study. Nanomaterials 2019, 9, 236.

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