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Nanomaterials 2019, 9(2), 211;

Detection of Histamine Dihydrochloride at Low Concentrations Using Raman Spectroscopy Enhanced by Gold Nanostars Colloids

Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología, Universidad Autónoma de San Luis Potosí, 78210 San Luis Potosí, Mexico
Applied Optics Complutense Group, Faculty of Optics and Optometry, University Complutense of Madrid, Av. Arcos de Jalon, 118, 28037 Madrid, Spain
Instituto de Física Luis Terrazas, Benemerita Universidad Autónoma de Puebla, Av. San Claudio, 18, 72570 Puebla, Mexico
Doctorado Institucional en Ingeniería y Ciencias de Materiales, Universidad Autónoma de San Luis Potosí, 78210 San Luis Potosí, Mexico
Author to whom correspondence should be addressed.
Received: 20 December 2018 / Revised: 16 January 2019 / Accepted: 22 January 2019 / Published: 6 February 2019
(This article belongs to the Special Issue Biomedical Applications of Nanoparticles)
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In this paper, we report a fast and easy method to detect histamine dihydrochloride using gold nanostars in colloidal aqueous solution as a highly active SERS platform with potential applications in biomedicine and food science. This colloid was characterized with SEM and UV–Vis spectroscopy. Also, numerical calculations were performed to estimate the plasmonic resonance and electric field amplification of the gold nanoparticles to compare the difference between nanospheres and nanostars. Finally, aqueous solutions of histamine dihydrochloride were prepared in a wide range of concentrations and the colloid was added to carry out SERS. We found SERS amplified the Raman signal of histamine by an enhancement factor of 1.0 × 10 7 , demonstrating the capability of the method to detect low concentrations of this amine molecule. View Full-Text
Keywords: SERS; histamine; nanostars; nanophotonics; computational electromagnetism SERS; histamine; nanostars; nanophotonics; computational electromagnetism

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Kolosovas-Machuca, E.S.; Cuadrado, A.; Ojeda-Galván, H.J.; Ortiz-Dosal, L.C.; Hernández-Arteaga, A.C.; Rodríguez-Aranda, M.C.; Navarro-Contreras, H.R.; Alda, J.; González, F.J. Detection of Histamine Dihydrochloride at Low Concentrations Using Raman Spectroscopy Enhanced by Gold Nanostars Colloids. Nanomaterials 2019, 9, 211.

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