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Dendrimers as Soft Nanomaterials for Electrochemical Immunosensors

Nanosensors & Nanomachines Group, Department of Analytical Chemistry, Complutense University of Madrid, 28040 Madrid, Spain
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Nanomaterials 2019, 9(12), 1745; https://doi.org/10.3390/nano9121745
Received: 28 October 2019 / Revised: 1 December 2019 / Accepted: 3 December 2019 / Published: 7 December 2019
(This article belongs to the Special Issue Nanomaterials for Immunosensors and DNA Sensors)
Electrochemical immunosensors are antibody-based affinity biosensors with a high impact on clinical, environmental, food, and pharmaceutical analysis. In general, the analytical performance of these devices is critically determined by the materials and reagents used for their construction, signal production and amplification. Dendrimers are monodisperse and highly branched polymers with three-dimensional structures widely employed as “soft” nanomaterials in electrochemical immunosensor technology. This review provides an overview on the state-of-the-art in dendrimer-based electrochemical immunosensors, focusing on those using polyamidoamine and poly (propylene imine) dendrimers. Special emphasis is given to the most original methods recently reported for the construction of immunosensor architectures incorporating dendrimers, as well as to novel sensing approaches based on dendrimer-assisted signal enhancement strategies. View Full-Text
Keywords: antibody; dendrimer; electrochemical immunosensor; polyamidoamine; poly (propylene imine) antibody; dendrimer; electrochemical immunosensor; polyamidoamine; poly (propylene imine)
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Sánchez, A.; Villalonga, A.; Martínez-García, G.; Parrado, C.; Villalonga, R. Dendrimers as Soft Nanomaterials for Electrochemical Immunosensors. Nanomaterials 2019, 9, 1745.

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