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Nanomaterials towards Biosensing of Alzheimer’s Disease Biomarkers

LEPABE–Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal
REQUIMTE–LAQV, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, R. Dr. António Bernardino de Almeida 431, 4200-072 Porto, Portugal
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(12), 1663;
Received: 28 October 2019 / Revised: 13 November 2019 / Accepted: 20 November 2019 / Published: 22 November 2019
(This article belongs to the Special Issue Nanomaterials for Immunosensors and DNA Sensors)
Alzheimer’s disease (AD) is an incurable and highly debilitating condition characterized by the progressive degeneration and/or death of nerve cells, which leads to manifestation of disabilities in cognitive functioning. In recent years, the development of biosensors for determination of AD’s main biomarkers has made remarkable progress, particularly based on the tremendous advances in nanoscience and nanotechnology. The unique and outstanding properties of nanomaterials (such as graphene, carbon nanotubes, gold, silver and magnetic nanoparticles, polymers and quantum dots) have been contributing to enhance the electrochemical and optical behavior of transducers while offering a suitable matrix for the immobilization of biological recognition elements. Therefore, optical and electrochemical immuno- and DNA-biosensors with higher sensitivity, selectivity and longer stability have been reported. Nevertheless, strategies based on the detection of multiple analytes still need to be improved, as they will play a crucial role in minimizing misdiagnosis. This review aims to provide insights into the conjugation of nanomaterials with different transducers highlighting their crucial role in the construction of biosensors for detection of AD main biomarkers. View Full-Text
Keywords: nanomaterials; electrochemical; optical; immunosensor; DNA sensor; biosensor; gold nanoparticles; carbon nanotubes; graphene; polymers nanomaterials; electrochemical; optical; immunosensor; DNA sensor; biosensor; gold nanoparticles; carbon nanotubes; graphene; polymers
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MDPI and ACS Style

Carneiro, P.; Morais, S.; Pereira, M.C. Nanomaterials towards Biosensing of Alzheimer’s Disease Biomarkers. Nanomaterials 2019, 9, 1663.

AMA Style

Carneiro P, Morais S, Pereira MC. Nanomaterials towards Biosensing of Alzheimer’s Disease Biomarkers. Nanomaterials. 2019; 9(12):1663.

Chicago/Turabian Style

Carneiro, Pedro, Simone Morais, and Maria Carmo Pereira. 2019. "Nanomaterials towards Biosensing of Alzheimer’s Disease Biomarkers" Nanomaterials 9, no. 12: 1663.

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