Antibacterial Activity Against Methicillin-Resistant Staphylococcus aureus of Colloidal Polydopamine Prepared by Carbon Dot Stimulated Polymerization of Dopamine
by
Moorthy Maruthapandi 1, Michal Natan 2, Gila Jacobi 2, Ehud Banin 2, John H. T. Luong 3 and Aharon Gedanken 1,*
Moorthy Maruthapandi 1, Michal Natan 2, Gila Jacobi 2, Ehud Banin 2, John H. T. Luong 3 and Aharon Gedanken 1,*
1
Department of Chemistry, Institute for Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan 52900, Israel
2
The Mina and Everard Goodman Faculty of Life Sciences, Institute for Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan 52900, Israel
3
School of Chemistry, University College Cork, Cork T12 YN60, Ireland
*
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(12), 1731; https://doi.org/10.3390/nano9121731
Received: 12 November 2019 / Revised: 20 November 2019 / Accepted: 30 November 2019 / Published: 4 December 2019
A simple one-step process for the polymerization of dopamine has been developed using nitrogen-doped carbon dots ([email protected]–dots) as the sole initiator. The synthesized amorphous polydopamine (PDA)-doped [email protected]–dots (PDA–[email protected]–dots composite) exhibited a negative charge of –39 mV with particle sizes ranging from 200 to 1700 nm. The stable colloidal solution was active against methicillin-resistant Staphylococcus aureus (MRSA), a Gram-negative bacterium. The strong adhesion of the polymer to the bacterial membrane resulted in a limited diffusion of nutrients and wastes in and out of the cell cytosol, which is a generic mechanism to trigger cell death. Another possible route is the autoxidation of the catechol moiety of PDA to form quinone and release reactive oxygen species (ROS) such as superoxide radicle and hydrogen peroxide, two well-known ROS with antimicrobial properties against both Gram-negative and Gram-positive bacteria.
Keywords:
carbon dots; polydopamine; colloidal dispersion; Staphylococcus aureus; eradication of MRSA
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MDPI and ACS Style
Maruthapandi, M.; Natan, M.; Jacobi, G.; Banin, E.; Luong, J.H.T.; Gedanken, A. Antibacterial Activity Against Methicillin-Resistant Staphylococcus aureus of Colloidal Polydopamine Prepared by Carbon Dot Stimulated Polymerization of Dopamine. Nanomaterials 2019, 9, 1731.
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