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Graphene Oxide-Based Biosensors for Liquid Biopsies in Cancer Diagnosis

1
Department of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 300, Taiwan
2
Institute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 300, Taiwan
3
Division of Haematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital (Linkou), Taoyuan 333, Taiwan
4
School of Chemical Engineering, University of New South Wales, Sydney, NSW 2052, Australia
5
Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 300, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nanomaterials 2019, 9(12), 1725; https://doi.org/10.3390/nano9121725
Received: 4 November 2019 / Revised: 25 November 2019 / Accepted: 25 November 2019 / Published: 3 December 2019
(This article belongs to the Special Issue Graphene-Based Materials for Cancer Therapy)
Liquid biopsies use blood or urine as test samples, which are able to be continuously collected in a non-invasive manner. The analysis of cancer-related biomarkers such as circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), microRNA, and exosomes provides important information in early cancer diagnosis, tumor metastasis detection, and postoperative recurrence monitoring assist with clinical diagnosis. However, low concentrations of some tumor markers, such as CTCs, ctDNA, and microRNA, in the blood limit its applications in clinical detection and analysis. Nanomaterials based on graphene oxide have good physicochemical properties and are now widely used in biomedical detection technologies. These materials have properties including good hydrophilicity, mechanical flexibility, electrical conductivity, biocompatibility, and optical performance. Moreover, utilizing graphene oxide as a biosensor interface has effectively improved the sensitivity and specificity of biosensors for cancer detection. In this review, we discuss various cancer detection technologies regarding graphene oxide and discuss the prospects and challenges of this technology. View Full-Text
Keywords: liquid biopsy; circulating tumor cells; circulating tumor DNA; exosome; graphene oxide liquid biopsy; circulating tumor cells; circulating tumor DNA; exosome; graphene oxide
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Chen, S.-L.; Chen, C.-Y.; Hsieh, J. .-H.; Yu, Z.-Y.; Cheng, S.-J.; Hsieh, K.Y.; Yang, J.-W.; Kumar, P.V.; Lin, S.-F.; Chen, G.-Y. Graphene Oxide-Based Biosensors for Liquid Biopsies in Cancer Diagnosis. Nanomaterials 2019, 9, 1725.

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