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Open AccessArticle

Ag/H-ZIF-8 Nanocomposite as an Effective Antibacterial Agent Against Pathogenic Bacteria

by Yanmei Zhang 1,2,*, Xin Zhang 1,2, Jie Song 1,2, Liming Jin 1,2, Xiaotong Wang 1,2 and Chunshan Quan 1,2,*
1
College of Life Science, Dalian Minzu University, Economical and Technological Development Zone, Dalian 116600, China
2
Key Laboratory of Biotechnology and Bioresources Utilization, Dalian Minzu University, Ministry of Education, Dalian 116600, China
*
Authors to whom correspondence should be addressed.
Nanomaterials 2019, 9(11), 1579; https://doi.org/10.3390/nano9111579
Received: 24 September 2019 / Revised: 27 October 2019 / Accepted: 29 October 2019 / Published: 7 November 2019
Development of antimicrobial nanomaterials is one of the most attractive strategies for eliminating the major threat of pathogenic bacteria to public health. In this work, we developed a simple impregnation-reduction method for the synthesis of Ag-doped hierarchical ZIF-8 (Ag/H-ZIF-8) nanocomposite. The nanocomposite was characterized by several techniques and its antibacterial activity was investigated. The Ag nanoparticles are uniformly dispersed in the porous ZIF-8 with narrow size distribution. Consequently, the resulting Ag/H-ZIF-8 nanocomposite showed significantly enhanced antibacterial activities compared to the single ZIF-8 or Ag nanoparticles. Furthermore, the composite is biocompatible, because no obvious toxicity was observed on Hepatic epithelial cells. This study offers a new approach for the design of hybrid antimicrobial nanomaterials that have great potentials in practical disinfections. View Full-Text
Keywords: Ag nanoparticles; hierarchical; ZIF-8; antibacterial activities; synergistic effect Ag nanoparticles; hierarchical; ZIF-8; antibacterial activities; synergistic effect
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MDPI and ACS Style

Zhang, Y.; Zhang, X.; Song, J.; Jin, L.; Wang, X.; Quan, C. Ag/H-ZIF-8 Nanocomposite as an Effective Antibacterial Agent Against Pathogenic Bacteria. Nanomaterials 2019, 9, 1579.

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