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Open AccessArticle

Hyaluronate Functionalized Multi-Wall Carbon Nanotubes Filled with Carboplatin as a Novel Drug Nanocarrier against Murine Lung Cancer Cells

1
Departamento de Histología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey C.P. 64460, Mexico
2
Departamento de Genética Molecular, Centro de Investigación Biomédica del Noreste (CIBIN) del IMSS, Monterrey C.P. 64720, Mexico
3
Escuela de Ingeniería y Ciencias, Tecnológico de Monterrey, Monterrey C.P. 64849, Mexico
4
Escuela de Medicina, Tecnológico de Monterrey, Monterrey 64849, Mexico
*
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(11), 1572; https://doi.org/10.3390/nano9111572
Received: 24 September 2019 / Revised: 23 October 2019 / Accepted: 26 October 2019 / Published: 6 November 2019
(This article belongs to the Special Issue Multifunctional Nanocarriers for Drug Delivery)
Carbon nanotubes (CNTs) have emerged in recent years as a potential option for drug delivery, due to their high functionalization capacity. Biocompatibility and selectivity using tissue-specific biomolecules can optimize the specificity, pharmacokinetics and stability of the drug. In this study, we design, develop and characterize a drug nanovector (oxCNTs-HA-CPT) conjugating oxidated multi-wall carbon nanotubes (oxCNTs) with hyaluronate (HA) and carboplatin (CPT) as a treatment in a lung cancer model in vitro. Subsequently, we exposed TC–1 and NIH/3T3 cell lines to the nanovectors and measured cell uptake, cell viability, and oxidative stress induction. The characterization of oxCNTs-HA-CPT reveals that on their surface, they have HA. On the other hand, oxCNTs-HA-CPT were endocytosed in greater proportion by tumor cells than by fibroblasts, and likewise, the cytotoxic effect was significantly higher in tumor cells. These results show the therapeutic potential that nanovectors possess; however, future studies should be carried out to determine the death pathways involved, as well as their effect on in vivo models. View Full-Text
Keywords: multi-wall carbon nanotubes; nanomedicine; tumor cells; hyaluronate; carboplatin multi-wall carbon nanotubes; nanomedicine; tumor cells; hyaluronate; carboplatin
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Salas-Treviño, D.; Saucedo-Cárdenas, O.; Loera-Arias, M.J.; Rodríguez-Rocha, H.; García-García, A.; Montes-de-Oca-Luna, R.; Piña-Mendoza, E.I.; Contreras-Torres, F.F.; García-Rivas, G.; Soto-Domínguez, A. Hyaluronate Functionalized Multi-Wall Carbon Nanotubes Filled with Carboplatin as a Novel Drug Nanocarrier against Murine Lung Cancer Cells. Nanomaterials 2019, 9, 1572.

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