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Open AccessReview

Multifunctional Nanocarriers for Lung Drug Delivery

by Jorge F. Pontes 1,2 and Ana Grenha 1,2,3,*
1
Centre for Marine Sciences (CCMAR), Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal
2
Drug Delivery Laboratory, Centre for Biomedical Research (CBMR), Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal
3
Department of Chemistry and Pharmacy, Faculty of Sciences and Technology, Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(2), 183; https://doi.org/10.3390/nano10020183
Received: 10 December 2019 / Revised: 15 January 2020 / Accepted: 17 January 2020 / Published: 21 January 2020
(This article belongs to the Special Issue Multifunctional Nanocarriers for Drug Delivery)
Nanocarriers have been increasingly proposed for lung drug delivery applications. The strategy of combining the intrinsic and more general advantages of the nanostructures with specificities that improve the therapeutic outcomes of particular clinical situations is frequent. These include the surface engineering of the carriers by means of altering the material structure (i.e., chemical modifications), the addition of specific ligands so that predefined targets are reached, or even the tuning of the carrier properties to respond to specific stimuli. The devised strategies are mainly directed at three distinct areas of lung drug delivery, encompassing the delivery of proteins and protein-based materials, either for local or systemic application, the delivery of antibiotics, and the delivery of anticancer drugs—the latter two comprising local delivery approaches. This review addresses the applications of nanocarriers aimed at lung drug delivery of active biological and pharmaceutical ingredients, focusing with particular interest on nanocarriers that exhibit multifunctional properties. A final section addresses the expectations regarding the future use of nanocarriers in the area. View Full-Text
Keywords: antibiotics; cancer; drug delivery; lung delivery; nanocarriers; nanopharmaceuticals; proteins antibiotics; cancer; drug delivery; lung delivery; nanocarriers; nanopharmaceuticals; proteins
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Pontes, J.F.; Grenha, A. Multifunctional Nanocarriers for Lung Drug Delivery. Nanomaterials 2020, 10, 183.

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