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Communication

Preparation of Hydrogen Peroxide Sensitive Nanofilms by a Layer-by-Layer Technique

1
School of Pharmaceutical Sciences, Ohu University 31-1 Misumido, Tomita-machi, Koriyama, Fukushima 963-8611, Japan
2
Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan
*
Author to whom correspondence should be addressed.
Nanomaterials 2018, 8(11), 941; https://doi.org/10.3390/nano8110941
Received: 24 October 2018 / Revised: 14 November 2018 / Accepted: 14 November 2018 / Published: 15 November 2018
H2O2-sensitive nanofilms composed of DNA and hemin-appended poly(ethyleneimine) (H-PEI) were prepared by a layer-by-layer deposition of DNA and H-PEI through an electrostatic interaction. The (H-PEI/DNA)5 film was decomposed by addition of 10 mM H2O2. H2O2-induced decomposition was also confirmed in the hemin-containing (PEI/DNA)5 in which hemin molecules were adsorbed by a noncovalent bond to the nanofilm. On the other hand, the (PEI/DNA)5 film containing no hemin and the (H-PEI/PSS)5 film using PSS instead of DNA did not decompose even with 100 mM H2O2. The mechanism of nanofilm decomposition was thought that more reactive oxygen species (ROS) was formed by reaction of hemin and H2O2 and then the ROS caused DNA cleavage. As a result (H-PEI/DNA)5 and hemin-containing (PEI/DNA)5 films were decomposed. The decomposition rate of these nanofilms were depended on concentration of H2O2, modification ratio of hemin, pH, and ionic strength. View Full-Text
Keywords: hydrogen peroxide response; layer-by-layer; multilayer thin film; nanofilm; stimuli-sensitive hydrogen peroxide response; layer-by-layer; multilayer thin film; nanofilm; stimuli-sensitive
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MDPI and ACS Style

Yoshida, K.; Ono, T.; Dairaku, T.; Kashiwagi, Y.; Sato, K. Preparation of Hydrogen Peroxide Sensitive Nanofilms by a Layer-by-Layer Technique. Nanomaterials 2018, 8, 941. https://doi.org/10.3390/nano8110941

AMA Style

Yoshida K, Ono T, Dairaku T, Kashiwagi Y, Sato K. Preparation of Hydrogen Peroxide Sensitive Nanofilms by a Layer-by-Layer Technique. Nanomaterials. 2018; 8(11):941. https://doi.org/10.3390/nano8110941

Chicago/Turabian Style

Yoshida, Kentaro, Tetsuya Ono, Takenori Dairaku, Yoshitomo Kashiwagi, and Katsuhiko Sato. 2018. "Preparation of Hydrogen Peroxide Sensitive Nanofilms by a Layer-by-Layer Technique" Nanomaterials 8, no. 11: 941. https://doi.org/10.3390/nano8110941

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