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Open AccessArticle

Magnetic Alginate/Chitosan Nanoparticles for Targeted Delivery of Curcumin into Human Breast Cancer Cells

1
Department of Chemical and Biological Engineering, University of Sheffield, Sheffield S1 3JD, UK
2
School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou 213164, China
3
Department of Materials Science and Engineering, University of Sheffield, Sheffield S1 3JD, UK
4
Department of Electronic and Electrical Engineering, University of Sheffield, Sheffield S3 7HQ, UK
*
Author to whom correspondence should be addressed.
Nanomaterials 2018, 8(11), 907; https://doi.org/10.3390/nano8110907
Received: 27 September 2018 / Revised: 26 October 2018 / Accepted: 2 November 2018 / Published: 5 November 2018
(This article belongs to the Special Issue Biomedical Applications of Nanoparticles)
Curcumin is a promising anti-cancer drug, but its applications in cancer therapy are limited, due to its poor solubility, short half-life and low bioavailability. In this study, curcumin loaded magnetic alginate/chitosan nanoparticles were fabricated to improve the bioavailability, uptake efficiency and cytotoxicity of curcumin to Human Caucasian Breast Adenocarcinoma cells (MDA-MB-231). Alginate and chitosan were deposited on Fe3O4 magnetic nanoparticles based on their electrostatic properties. The nanoparticle size ranged from 120–200 nm, within the optimum range for drug delivery. Controllable and sustained release of curcumin was obtained by altering the number of chitosan and alginate layers on the nanoparticles. Confocal fluorescence microscopy results showed that targeted delivery of curcumin with the aid of a magnetic field was achieved. The fluorescence-activated cell sorting (FACS) assay indicated that MDA-MB-231 cells treated with curcumin loaded nanoparticles had a 3–6 fold uptake efficiency to those treated with free curcumin. The 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay indicated that the curcumin loaded nanoparticles exhibited significantly higher cytotoxicity towards MDA-MB-231 cells than HDF cells. The sustained release profiles, enhanced uptake efficiency and cytotoxicity to cancer cells, as well as directed targeting make MACPs promising candidates for cancer therapy. View Full-Text
Keywords: alginate; chitosan; layer-by-layer; magnetic nanoparticles; drug delivery; cancer; curcumin alginate; chitosan; layer-by-layer; magnetic nanoparticles; drug delivery; cancer; curcumin
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MDPI and ACS Style

Song, W.; Su, X.; Gregory, D.A.; Li, W.; Cai, Z.; Zhao, X. Magnetic Alginate/Chitosan Nanoparticles for Targeted Delivery of Curcumin into Human Breast Cancer Cells. Nanomaterials 2018, 8, 907.

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