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Lipid-Based Nanoparticles as a Potential Delivery Approach in the Treatment of Rheumatoid Arthritis

by 1,†, 2,†, 3,4,5 and 1,6,7,8,*
1
Research Center for Food and Cosmetic Safety and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Kweishan, Taoyuan 333, Taiwan
2
Center for General Education, Chang Gung University of Science and Technology, Kweishan, Taoyuan 333, Taiwan
3
Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Keelung 204, Taiwan
4
School of Traditional Chinese Medicine, Chang Gung University, Taoyuan 333, Taiwan
5
School of Nursing, National Taipei University of Nursing and Health Sciences, Taipei 112, Taiwan
6
Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan 333, Taiwan
7
Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Kweishan, Taoyuan 333, Taiwan
8
Department of Anesthesiology, Chang Gung Memorial Hospital, Linkou, Taoyuan 333, Taiwan
*
Author to whom correspondence should be addressed.
This authors contributed equally in this work.
Nanomaterials 2018, 8(1), 42; https://doi.org/10.3390/nano8010042
Received: 24 November 2017 / Revised: 10 January 2018 / Accepted: 12 January 2018 / Published: 15 January 2018
(This article belongs to the Special Issue Pharmaceutical Nanotechnology)
Rheumatoid arthritis (RA), a chronic and joint-related autoimmune disease, results in immune dysfunction and destruction of joints and cartilages. Small molecules and biological therapies have been applied in a wide variety of inflammatory disorders, but their utility as a therapeutic agent is limited by poor absorption, rapid metabolism, and serious side effects. To improve these limitations, nanoparticles, which are capable of encapsulating and protecting drugs from degradation before they reach the target site in vivo, may serve as drug delivery systems. The present research proposes a platform for different lipid nanoparticle approaches for RA therapy, taking advantage of the newly emerging field of lipid nanoparticles to develop a targeted theranostic system for application in the treatment of RA. This review aims to present the recent major application of lipid nanoparticles that provide a biocompatible and biodegradable delivery system to effectively improve RA targeting over free drugs via the presentation of tissue-specific targeting of ligand-controlled drug release by modulating nanoparticle composition. View Full-Text
Keywords: rheumatoid arthritis; lipid nanoparticle; liposome; drug delivery rheumatoid arthritis; lipid nanoparticle; liposome; drug delivery
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MDPI and ACS Style

Chuang, S.-Y.; Lin, C.-H.; Huang, T.-H.; Fang, J.-Y. Lipid-Based Nanoparticles as a Potential Delivery Approach in the Treatment of Rheumatoid Arthritis. Nanomaterials 2018, 8, 42. https://doi.org/10.3390/nano8010042

AMA Style

Chuang S-Y, Lin C-H, Huang T-H, Fang J-Y. Lipid-Based Nanoparticles as a Potential Delivery Approach in the Treatment of Rheumatoid Arthritis. Nanomaterials. 2018; 8(1):42. https://doi.org/10.3390/nano8010042

Chicago/Turabian Style

Chuang, Shih-Yi; Lin, Chih-Hung; Huang, Tse-Hung; Fang, Jia-You. 2018. "Lipid-Based Nanoparticles as a Potential Delivery Approach in the Treatment of Rheumatoid Arthritis" Nanomaterials 8, no. 1: 42. https://doi.org/10.3390/nano8010042

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