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10.3390/nano13030414
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Article

Smart Nanofiber Mesh with Locally Sustained Drug Release Enabled Synergistic Combination Therapy for Glioblastoma

by
Yinuo Li
1,
Yoshitaka Matsumoto
2,3,*,
Lili Chen
4,
Yu Sugawara
3,
Emiho Oe
4,5,
Nanami Fujisawa
4,5,
Mitsuhiro Ebara
4 and
Hideyuki Sakurai
2,3
1
Department of Radiation Oncology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8575, Japan
2
Department of Radiation Oncology, Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
3
Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba 305-8576, Japan
4
Research Center for Functional Materials, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, Japan
5
Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba 305-0006, Japan
*
Author to whom correspondence should be addressed.
Nanomaterials 2023, 13(3), 414; https://doi.org/10.3390/nano13030414
Submission received: 29 December 2022 / Revised: 16 January 2023 / Accepted: 17 January 2023 / Published: 19 January 2023
(This article belongs to the Special Issue Biohybrid Nanofibers and Nanomaterial-Contained Fibers: Fabrication and Application)
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Abstract

This study aims to propose a new treatment model for glioblastoma (GBM). The combination of chemotherapy, molecular targeted therapy and radiotherapy has been achieved in a highly simultaneous manner through the application of a safe, non-toxic, locally sustained drug-releasing composite Nanofiber mesh (NFM). The NFM consisted of biodegradable poly(ε-caprolactone) with temozolomide (TMZ) and 17-allylamino-17-demethoxygeldanamycin (17AAG), which was used in radiation treatment. TMZ and 17AAG combination showed a synergistic cytotoxicity effect in the T98G cell model. TMZ and 17AAG induced a radiation-sensitization effect, respectively. The NFM containing 17AAG or TMZ, known as 17AAG-NFM and TMZ-NFM, enabled cumulative drug release of 34.1% and 39.7% within 35 days. Moreover, 17AAG+TMZ-NFM containing both drugs revealed a synergistic effect in relation to the NFM of a single agent. When combined with radiation, 17AAG+TMZ-NFM induced in an extremely powerful cytotoxic effect. These results confirmed the application of NFM can simultaneously allow multiple treatments to T98G cells. Each modality achieved a significant synergistic effect with the other, leading to a cascading amplification of the therapeutic effect. Due to the superior advantage of sustained drug release over a long period of time, NFM has the promise of clinically addressing the challenge of high recurrence of GBM post-operatively.
Keywords: glioblastoma; combination therapy; synergistic effect; TMZ; 17AAG; radiation therapy; radiosensitization; nanofiber glioblastoma; combination therapy; synergistic effect; TMZ; 17AAG; radiation therapy; radiosensitization; nanofiber

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MDPI and ACS Style

Li, Y.; Matsumoto, Y.; Chen, L.; Sugawara, Y.; Oe, E.; Fujisawa, N.; Ebara, M.; Sakurai, H. Smart Nanofiber Mesh with Locally Sustained Drug Release Enabled Synergistic Combination Therapy for Glioblastoma. Nanomaterials 2023, 13, 414. https://doi.org/10.3390/nano13030414

AMA Style

Li Y, Matsumoto Y, Chen L, Sugawara Y, Oe E, Fujisawa N, Ebara M, Sakurai H. Smart Nanofiber Mesh with Locally Sustained Drug Release Enabled Synergistic Combination Therapy for Glioblastoma. Nanomaterials. 2023; 13(3):414. https://doi.org/10.3390/nano13030414

Chicago/Turabian Style

Li, Yinuo, Yoshitaka Matsumoto, Lili Chen, Yu Sugawara, Emiho Oe, Nanami Fujisawa, Mitsuhiro Ebara, and Hideyuki Sakurai. 2023. "Smart Nanofiber Mesh with Locally Sustained Drug Release Enabled Synergistic Combination Therapy for Glioblastoma" Nanomaterials 13, no. 3: 414. https://doi.org/10.3390/nano13030414

APA Style

Li, Y., Matsumoto, Y., Chen, L., Sugawara, Y., Oe, E., Fujisawa, N., Ebara, M., & Sakurai, H. (2023). Smart Nanofiber Mesh with Locally Sustained Drug Release Enabled Synergistic Combination Therapy for Glioblastoma. Nanomaterials, 13(3), 414. https://doi.org/10.3390/nano13030414

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