Next Article in Journal
Air Stabilization of Li7P3S11 Solid-State Electrolytes through Laser-Based Processing
Previous Article in Journal
Synergistic Effects of Localized Surface Plasmon Resonance, Surface Plasmon Polariton, and Waveguide Plasmonic Resonance on the Same Material: A Promising Hypothesis to Enhance Organic Solar Cell Efficiency
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nanomaterials
Volume 13
Issue 15
10.3390/nano13152208
nanomaterials-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Nanoceria as Safe Contrast Agents for X-ray CT Imaging

by
Ana García
1,
Juan Antonio Cámara
2,
Ana María Boullosa
3,4,
Muriel F. Gustà
4,5,
Laura Mondragón
1,5,
Simó Schwartz, Jr.
3,4,6,
Eudald Casals
7,
Ibane Abasolo
3,4,6,
Neus G. Bastús
4,5 and
Víctor Puntes
1,4,5,8,*
1
Design and Pharmacokinetics of Nanoparticles, CIBBIM-Nanomedicine, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Passeig Vall d’Hebron 119-129, 08035 Barcelona, Spain
2
Preclinical Imaging Platform, Vall d’Hebron Institute of Research (VHIR), Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain
3
Clinical Biochemistry, Drug Delivery & Targeting (CB-DDT), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Passeig Vall d’Hebron 119-129, 08035 Barcelona, Spain
4
Networking Research Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 08034 Barcelona, Spain
5
Institut Català de Nanociència i Nanotecnologia (ICN2), Consejo Superior de Investigaciones Científicas (CSIC), The Barcelona Institute of Science and Technology (BIST), 08036 Barcelona, Spain
6
Servei de Bioquímica, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Passeig Vall d’Hebron 119-129, 08035 Barcelona, Spain
7
School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China
8
Institut Català de Recerca i Estudis Avançats, (ICREA), P. Lluis Companys 23, 08010 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Nanomaterials 2023, 13(15), 2208; https://doi.org/10.3390/nano13152208
Submission received: 30 June 2023 / Revised: 24 July 2023 / Accepted: 27 July 2023 / Published: 29 July 2023
Browse Figures
Review Reports Versions Notes

Abstract

Cerium oxide nanoparticles (CeO2NPs) have exceptional catalytic properties, rendering them highly effective in removing excessive reactive oxygen species (ROS) from biological environments, which is crucial in safeguarding these environments against radiation-induced damage. Additionally, the Ce atom’s high Z number makes it an ideal candidate for utilisation as an X-ray imaging contrast agent. We herein show how the injection of albumin-stabilised 5 nm CeO2NPs into mice revealed substantial enhancement in X-ray contrast, reaching up to a tenfold increase at significantly lower concentrations than commercial or other proposed contrast agents. Remarkably, these NPs exhibited prolonged residence time within the target organs. Thus, upon injection into the tail vein, they exhibited efficient uptake by the liver and spleen, with 85% of the injected dose (%ID) recovered after 7 days. In the case of intratumoral administration, 99% ID of CeO2NPs remained within the tumour throughout the 7-day observation period, allowing for observation of disease dynamics. Mass spectrometry (ICP-MS) elemental analysis confirmed X-ray CT imaging observations.
Keywords: nanoceria; CeO2 nanoparticles; X-ray CT imaging; reactive oxygen species scavengers nanoceria; CeO2 nanoparticles; X-ray CT imaging; reactive oxygen species scavengers

Share and Cite

MDPI and ACS Style

García, A.; Cámara, J.A.; Boullosa, A.M.; Gustà, M.F.; Mondragón, L.; Schwartz, S., Jr.; Casals, E.; Abasolo, I.; Bastús, N.G.; Puntes, V. Nanoceria as Safe Contrast Agents for X-ray CT Imaging. Nanomaterials 2023, 13, 2208. https://doi.org/10.3390/nano13152208

AMA Style

García A, Cámara JA, Boullosa AM, Gustà MF, Mondragón L, Schwartz S Jr., Casals E, Abasolo I, Bastús NG, Puntes V. Nanoceria as Safe Contrast Agents for X-ray CT Imaging. Nanomaterials. 2023; 13(15):2208. https://doi.org/10.3390/nano13152208

Chicago/Turabian Style

García, Ana, Juan Antonio Cámara, Ana María Boullosa, Muriel F. Gustà, Laura Mondragón, Simó Schwartz, Jr., Eudald Casals, Ibane Abasolo, Neus G. Bastús, and Víctor Puntes. 2023. "Nanoceria as Safe Contrast Agents for X-ray CT Imaging" Nanomaterials 13, no. 15: 2208. https://doi.org/10.3390/nano13152208

APA Style

García, A., Cámara, J. A., Boullosa, A. M., Gustà, M. F., Mondragón, L., Schwartz, S., Jr., Casals, E., Abasolo, I., Bastús, N. G., & Puntes, V. (2023). Nanoceria as Safe Contrast Agents for X-ray CT Imaging. Nanomaterials, 13(15), 2208. https://doi.org/10.3390/nano13152208

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop