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10.3390/nano12071153
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Article

Streamlined Fabrication of Hybrid Lipid Bilayer Membranes on Titanium Oxide Surfaces: A Comparison of One- and Two-Tail SAM Molecules

by
Tun Naw Sut
1,†,
Sue Woon Tan
1,†,
Won-Yong Jeon
1,
Bo Kyeong Yoon
2,*,
Nam-Joon Cho
3,* and
Joshua A. Jackman
1,*
1
School of Chemical Engineering and Translational Nanobioscience Research Center, Sungkyunkwan University, Suwon 16419, Korea
2
School of Healthcare and Biomedical Engineering, Chonnam National University, Yeosu 59626, Korea
3
School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Drive, Singapore 637553, Singapore
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nanomaterials 2022, 12(7), 1153; https://doi.org/10.3390/nano12071153
Submission received: 8 March 2022 / Revised: 29 March 2022 / Accepted: 29 March 2022 / Published: 30 March 2022
(This article belongs to the Special Issue Biobased Nanoscale Drug Delivery Systems)
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Abstract

There is broad interest in fabricating cell-membrane-mimicking, hybrid lipid bilayer (HLB) coatings on titanium oxide surfaces for medical implant and drug delivery applications. However, existing fabrication strategies are complex, and there is an outstanding need to develop a streamlined method that can be performed quickly at room temperature. Towards this goal, herein, we characterized the room-temperature deposition kinetics and adlayer properties of one- and two-tail phosphonic acid-functionalized molecules on titanium oxide surfaces in various solvent systems and identified optimal conditions to prepare self-assembled monolayers (SAMs), upon which HLBs could be formed in select cases. Among the molecular candidates, we identified a two-tail molecule that formed a rigidly attached SAM to enable HLB fabrication via vesicle fusion for membrane-based biosensing applications. By contrast, vesicles adsorbed but did not rupture on SAMs composed of one-tail molecules. Our findings support that two-tail phosphonic acid SAMs offer superior capabilities for rapid HLB coating fabrication at room temperature, and these streamlined capabilities could be useful to prepare durable lipid bilayer coatings on titanium-based materials.
Keywords: hybrid lipid bilayer; self-assembled monolayer; titanium oxide; surface functionalization hybrid lipid bilayer; self-assembled monolayer; titanium oxide; surface functionalization
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MDPI and ACS Style

Sut, T.N.; Tan, S.W.; Jeon, W.-Y.; Yoon, B.K.; Cho, N.-J.; Jackman, J.A. Streamlined Fabrication of Hybrid Lipid Bilayer Membranes on Titanium Oxide Surfaces: A Comparison of One- and Two-Tail SAM Molecules. Nanomaterials 2022, 12, 1153. https://doi.org/10.3390/nano12071153

AMA Style

Sut TN, Tan SW, Jeon W-Y, Yoon BK, Cho N-J, Jackman JA. Streamlined Fabrication of Hybrid Lipid Bilayer Membranes on Titanium Oxide Surfaces: A Comparison of One- and Two-Tail SAM Molecules. Nanomaterials. 2022; 12(7):1153. https://doi.org/10.3390/nano12071153

Chicago/Turabian Style

Sut, Tun Naw, Sue Woon Tan, Won-Yong Jeon, Bo Kyeong Yoon, Nam-Joon Cho, and Joshua A. Jackman. 2022. "Streamlined Fabrication of Hybrid Lipid Bilayer Membranes on Titanium Oxide Surfaces: A Comparison of One- and Two-Tail SAM Molecules" Nanomaterials 12, no. 7: 1153. https://doi.org/10.3390/nano12071153

APA Style

Sut, T. N., Tan, S. W., Jeon, W.-Y., Yoon, B. K., Cho, N.-J., & Jackman, J. A. (2022). Streamlined Fabrication of Hybrid Lipid Bilayer Membranes on Titanium Oxide Surfaces: A Comparison of One- and Two-Tail SAM Molecules. Nanomaterials, 12(7), 1153. https://doi.org/10.3390/nano12071153

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