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Article

Impact of Physico-Chemical Properties of Cellulose Nanocrystal/Silver Nanoparticle Hybrid Suspensions on Their Biocidal and Toxicological Effects

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INRAE, Institut National de Recherche Pour L’agriculture, L’alimentation et L’environnement, BIA, Biopolymères Interactions et Assemblages, 44316 Nantes, France
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Laboratoire de Chimie et Biologie des Métaux, University Grenoble Alpes, CNRS, CEA, IRIG, CBM, UMR5249, 38000 Grenoble, France
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SOLEIL Synchrotron, L’Orme des Merisiers, Gif-sur-Yvette, 91192 Saint-Aubin, France
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INRAE, Institut National de Recherche Pour L’agriculture, L’alimentation et L’environnement, BIA, TRANSFORM, 44316 Nantes, France
*
Authors to whom correspondence should be addressed.
Academic Editor: Alexey Pestryakov
Nanomaterials 2021, 11(7), 1862; https://doi.org/10.3390/nano11071862
Received: 16 June 2021 / Revised: 8 July 2021 / Accepted: 16 July 2021 / Published: 20 July 2021
(This article belongs to the Section Biology and Medicines)
There is a demand for nanoparticles that are environmentally acceptable, but simultaneously efficient and low cost. We prepared silver nanoparticles (AgNPs) grafted on a native bio-based substrate (cellulose nanocrystals, CNCs) with high biocidal activity and no toxicological impact. AgNPs of 10 nm are nucleated on CNCs in aqueous suspension with content from 0.4 to 24.7 wt%. XANES experiments show that varying the NaBH4/AgNO3 molar ratio affects the AgNP oxidation state, while maintaining an fcc structure. AgNPs transition from 10 nm spherical NPs to 300 nm triangular-shaped AgNPrisms induced by H2O2 post-treatment. The 48 h biocidal activity of the hybrid tested on B. Subtilis is intensified with the increase of AgNP content irrespective of the Ag+/Ag0 ratio in AgNPs, while the AgNSphere−AgNPrism transition induces a significant reduction of biocidal activity. A very low minimum inhibitory concentration of 0.016 mg AgNP/mL is determined. A new long-term biocidal activity test (up to 168 h) proved efficiency favorable to the smaller AgNPs. Finally, it is shown that AgNPs have no impact on the phagocytic capacity of mammalian cells. View Full-Text
Keywords: CNC/AgNP hybrids; NaBH4/AgNO3 molar ratio; H2O2 redox; oxidation state; short- and long-term biocidal effect; MIC; toxicology CNC/AgNP hybrids; NaBH4/AgNO3 molar ratio; H2O2 redox; oxidation state; short- and long-term biocidal effect; MIC; toxicology
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MDPI and ACS Style

Musino, D.; Devcic, J.; Lelong, C.; Luche, S.; Rivard, C.; Dalzon, B.; Landrot, G.; Rabilloud, T.; Capron, I. Impact of Physico-Chemical Properties of Cellulose Nanocrystal/Silver Nanoparticle Hybrid Suspensions on Their Biocidal and Toxicological Effects. Nanomaterials 2021, 11, 1862. https://doi.org/10.3390/nano11071862

AMA Style

Musino D, Devcic J, Lelong C, Luche S, Rivard C, Dalzon B, Landrot G, Rabilloud T, Capron I. Impact of Physico-Chemical Properties of Cellulose Nanocrystal/Silver Nanoparticle Hybrid Suspensions on Their Biocidal and Toxicological Effects. Nanomaterials. 2021; 11(7):1862. https://doi.org/10.3390/nano11071862

Chicago/Turabian Style

Musino, Dafne, Julie Devcic, Cécile Lelong, Sylvie Luche, Camille Rivard, Bastien Dalzon, Gautier Landrot, Thierry Rabilloud, and Isabelle Capron. 2021. "Impact of Physico-Chemical Properties of Cellulose Nanocrystal/Silver Nanoparticle Hybrid Suspensions on Their Biocidal and Toxicological Effects" Nanomaterials 11, no. 7: 1862. https://doi.org/10.3390/nano11071862

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