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Article

Enhancement of Chemical Stability and Dermal Delivery of Cordyceps militaris Extracts by Nanoemulsion

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Master’s Degree Program in Cosmetic Science, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
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Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
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Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Huachiew Chalermprakiet University, Samutprakarn 10250, Thailand
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Research Center of Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai 50200, Thailand
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Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand
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Department of Entomology and Plant Pathology, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(8), 1565; https://doi.org/10.3390/nano10081565
Received: 18 June 2020 / Revised: 25 July 2020 / Accepted: 6 August 2020 / Published: 9 August 2020
This study aimed to develop nanoemulsions for enhancing chemical stability and dermal delivery of Cordyceps militaris extracts. C. militaris was extracted by maceration and infusion. The extracts were investigated for cordycepin, phenolic, and flavonoid content. The antioxidant activity was investigated by in vitro spectrophotometric methods. The irritation profile was investigated by hen’s egg-chorioallantoic membrane test. Nanoemulsions were developed using high-pressure homogenizer. C. militaris extract was incorporated into the nanoemulsion and investigated for safety, release profile, permeation, and skin retention. The results demonstrated that water extract (CW) contained the significantly highest content of cordycepin, phenolics, and flavonoids, which were responsible for antioxidant activity. CW was the most potent antioxidant. CW possessed comparable 2,2′-diphenyl-1-picrylhydrazyl radical scavenging activity and lipid peroxidation inhibition to l-ascorbic acid (96.9 ± 3.1%) and alpha-tocopherol (87.2 ± 1.0%). Consequently, ten mg/mL of CW was incorporated into nanoemulsions composing of sugar squalene, Tween® 85, and deionized water. Nanoemulsion, which had the smallest internal droplet size (157.1 ± 2.6 nm), enhanced the stability of CW, had no cytotoxicity effect and no skin irritation, released the most CW (0.9 ± 0.0% w/w after 24 h), and delivered the highest CW into the skin layer (33.5 ± 0.7% w/w). Therefore, nanoemulsion was suggested for enhancing the stability and dermal delivery of CW. View Full-Text
Keywords: Cordyceps militaris; cordycepin; nanoemulsion; skin delivery; antioxidant; irritation Cordyceps militaris; cordycepin; nanoemulsion; skin delivery; antioxidant; irritation
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MDPI and ACS Style

Marsup, P.; Yeerong, K.; Neimkhum, W.; Sirithunyalug, J.; Anuchapreeda, S.; To-anun, C.; Chaiyana, W. Enhancement of Chemical Stability and Dermal Delivery of Cordyceps militaris Extracts by Nanoemulsion. Nanomaterials 2020, 10, 1565. https://doi.org/10.3390/nano10081565

AMA Style

Marsup P, Yeerong K, Neimkhum W, Sirithunyalug J, Anuchapreeda S, To-anun C, Chaiyana W. Enhancement of Chemical Stability and Dermal Delivery of Cordyceps militaris Extracts by Nanoemulsion. Nanomaterials. 2020; 10(8):1565. https://doi.org/10.3390/nano10081565

Chicago/Turabian Style

Marsup, Pachabadee, Kankanit Yeerong, Waranya Neimkhum, Jakkapan Sirithunyalug, Songyot Anuchapreeda, Chaiwat To-anun, and Wantida Chaiyana. 2020. "Enhancement of Chemical Stability and Dermal Delivery of Cordyceps militaris Extracts by Nanoemulsion" Nanomaterials 10, no. 8: 1565. https://doi.org/10.3390/nano10081565

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