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Open AccessArticle

Nanostructured Polyelectrolyte Complexes Based on Water-Soluble Thiacalix[4]Arene and Pillar[5]Arene: Self-Assembly in Micelleplexes and Polyplexes at Packaging DNA

A.M. Butlerov Chemical Institute, Kazan Federal University, Kremlevskaya Street, 18, 420008 Kazan, Russia
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Nanomaterials 2020, 10(4), 777; https://doi.org/10.3390/nano10040777
Received: 24 March 2020 / Revised: 14 April 2020 / Accepted: 15 April 2020 / Published: 17 April 2020
(This article belongs to the Special Issue Nanomaterials: 10th Anniversary)
Controlling the self-assembly of polyfunctional compounds in interpolyelectrolyte aggregates is an extremely challenging task. The use of macrocyclic compounds offers new opportunities in design of a new generation of mixed nanoparticles. This approach allows creating aggregates with multivalent molecular recognition, improved binding efficiency and selectivity. In this paper, we reported a straightforward approach to the synthesis of interpolyelectrolytes by co-assembling of the thiacalix[4]arene with four negatively charged functional groups on the one side of macrocycle, and pillar[5]arene with 10 ammonium groups located on both sides. Nanostructured polyelectrolyte complexes show effective packaging of high-molecular DNA from calf thymus. The interaction of co-interpolyelectrolytes with the DNA is completely different from the interaction of the pillar[5]arene with the DNA. Two different complexes with DNA, i.e., micelleplex- and polyplex-type, were formed. The DNA in both cases preserved its secondary structure in native B form without distorting helicity. The presented approach provides important advantage for the design of effective biomolecular gene delivery systems. View Full-Text
Keywords: nanomaterials; thiacalix[4]arene; pillar[5]arene; interpolyelectrolyte; co-assembly; selective recognition; DNA packing nanomaterials; thiacalix[4]arene; pillar[5]arene; interpolyelectrolyte; co-assembly; selective recognition; DNA packing
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Yakimova, L.S.; Nugmanova, A.R.; Mostovaya, O.A.; Vavilova, A.A.; Shurpik, D.N.; Mukhametzyanov, T.A.; Stoikov, I.I. Nanostructured Polyelectrolyte Complexes Based on Water-Soluble Thiacalix[4]Arene and Pillar[5]Arene: Self-Assembly in Micelleplexes and Polyplexes at Packaging DNA. Nanomaterials 2020, 10, 777.

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