Next Article in Journal
Florfenicol Binding to Molecularly Imprinted Polymer Nanoparticles in Model and Real Samples
Previous Article in Journal
Comparative Study of Synthesis Methods to Prepare New Functionalized Adsorbent Materials Based on MNPs–GO Coupling
Previous Article in Special Issue
ToxTracker Reporter Cell Lines as a Tool for Mechanism-Based (Geno)Toxicity Screening of Nanoparticles—Metals, Oxides and Quantum Dots
Open AccessArticle

Genotoxicity of Aluminum and Aluminum Oxide Nanomaterials in Rats Following Oral Exposure

1
Unité de Toxicologie des Contaminants, Agence Nationale de Sécurité Sanitaire (ANSES), 10 B rue Claude Bourgelat, 35306 Fougères, France
2
Institut Pasteur de Lille, Laboratoire de toxicologie génétique, 1 Rue du Professeur Calmette, 59019 Lille CEDEX, France
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(2), 305; https://doi.org/10.3390/nano10020305
Received: 9 January 2020 / Revised: 27 January 2020 / Accepted: 2 February 2020 / Published: 11 February 2020
Due to several gaps remaining in the toxicological evaluation of nanomaterials (NMs), consumers and public health agencies have shown increasing concern for human health protection. In addition to aluminum (Al) microparticles, Al-containing nanomaterials (Al NMs) have been applied by food industry as additives and contact materials. Due to the limited amount of literature on the toxicity of Al NMs, this study aimed to evaluate the in vivo genotoxic potential of Al0 and Al2O3 NMs after acute oral exposure. Male Sprague-Dawley rats were administered three successive gavages at 6, 12.5 and 25 mg/kg bw. A comparison with AlCl3 was done in order to assess the potential effect of dissolution into Al ions. Both DNA strand breaks and oxidative DNA damage were investigated in six organs/tissues (duodenum, liver, kidney, spleen, blood and bone marrow) with the alkaline and the Fpg-modified comet assays. Concomitantly, chromosomal damage was investigated in bone marrow and colon with the micronucleus assay. The comet assay only showed DNA damage with Al2O3 NMs in bone marrow (BM), while AlCl3 induced slight but non-significant oxidative DNA damage in blood. No increase of chromosomal mutations was observed after treatment with the two Al MNs either in the BM or in the colons of rats.
Keywords: genotoxicity; comet assay; micronucleus assay; nanomaterial; aluminum; oral route; gut; liver genotoxicity; comet assay; micronucleus assay; nanomaterial; aluminum; oral route; gut; liver
MDPI and ACS Style

Jalili, P.; Huet, S.; Lanceleur, R.; Jarry, G.; Le Hegarat, L.; Nesslany, F.; Hogeveen, K.; Fessard, V. Genotoxicity of Aluminum and Aluminum Oxide Nanomaterials in Rats Following Oral Exposure. Nanomaterials 2020, 10, 305.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop