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Synthesis of Cerium Oxide Nanoparticles Using Various Methods: Implications for Biomedical Applications

Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutics Sciences, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa
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Nanomaterials 2020, 10(2), 242; https://doi.org/10.3390/nano10020242
Received: 29 November 2019 / Revised: 13 January 2020 / Accepted: 14 January 2020 / Published: 29 January 2020
(This article belongs to the Special Issue Nanomaterials for Biomedical and Biotechnological Applications)
Cerium oxide nanoparticles have been used in a number of non-medical products over the years. The therapeutic application of these nanoparticles has mainly been due to their oxidative stress ameliorating abilities. Their enzyme-mimetic catalytic ability to change between the Ce3+ and Ce4+ species makes them ideal for a role as free-radical scavengers for systemic diseases as well as neurodegenerative diseases. In this review, we look at various methods of synthesis (including the use of stabilizing/capping agents and precursors), and how the synthesis method affects the physicochemical properties, their behavior in biological environments, their catalytic abilities as well as their reported toxicity. View Full-Text
Keywords: neurodegenerative disease; cerium oxide nanoparticles; Parkinson’s disease; oxidative stress; physicochemical properties; blood-brain barrier; synthesis methods neurodegenerative disease; cerium oxide nanoparticles; Parkinson’s disease; oxidative stress; physicochemical properties; blood-brain barrier; synthesis methods
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Nyoka, M.; Choonara, Y.E.; Kumar, P.; Kondiah, P.P.D.; Pillay, V. Synthesis of Cerium Oxide Nanoparticles Using Various Methods: Implications for Biomedical Applications. Nanomaterials 2020, 10, 242.

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