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Article

Novel Surface-Modified Bilosomes as Functional and Biocompatible Nanocarriers of Hybrid Compounds

Department of Physical and Quantum Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland
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Nanomaterials 2020, 10(12), 2472; https://doi.org/10.3390/nano10122472
Received: 21 November 2020 / Revised: 4 December 2020 / Accepted: 8 December 2020 / Published: 10 December 2020
(This article belongs to the Special Issue Functional Polymeric Nanoparticles)
In the present contribution, we demonstrate a new approach for functionalization of colloidal nanomaterial consisting of phosphatidylcholine/cholesterol-based vesicular systems modified by FDA-approved biocompatible components, i.e., sodium cholate hydrate acting as a biosurfactant and Pluronic P123—a symmetric triblock copolymer comprising poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) blocks Eight novel bilosome formulations were prepared using the thin-film hydration method followed by sonication and extrusion in combination with homogenization technique. The optimization studies involving the influence of the preparation technique on the nanocarrier size (dynamic light scattering), charge (electrophoretic light scattering), morphology (transmission electron microscopy) and kinetic stability (backscattering profiles) revealed the most promising candidate for the co-loading of model active compounds of various solubility; namely, hydrophilic methylene blue and hydrophobic curcumin. The studies of the hybrid cargo encapsulation efficiency (UV-Vis spectroscopy) exhibited significant potential of the formulated bilosomes in further biomedical and pharmaceutical applications, including drug delivery, anticancer treatment or diagnostics. View Full-Text
Keywords: polymeric bilosomes; biosurfactants; nanoparticles; drug delivery; anticancer treatment polymeric bilosomes; biosurfactants; nanoparticles; drug delivery; anticancer treatment
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MDPI and ACS Style

Waglewska, E.; Pucek-Kaczmarek, A.; Bazylińska, U. Novel Surface-Modified Bilosomes as Functional and Biocompatible Nanocarriers of Hybrid Compounds. Nanomaterials 2020, 10, 2472. https://doi.org/10.3390/nano10122472

AMA Style

Waglewska E, Pucek-Kaczmarek A, Bazylińska U. Novel Surface-Modified Bilosomes as Functional and Biocompatible Nanocarriers of Hybrid Compounds. Nanomaterials. 2020; 10(12):2472. https://doi.org/10.3390/nano10122472

Chicago/Turabian Style

Waglewska, Ewelina, Agata Pucek-Kaczmarek, and Urszula Bazylińska. 2020. "Novel Surface-Modified Bilosomes as Functional and Biocompatible Nanocarriers of Hybrid Compounds" Nanomaterials 10, no. 12: 2472. https://doi.org/10.3390/nano10122472

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