Perfluoropolyether Nanoemulsion Encapsulating Chlorin e6 for Sonodynamic and Photodynamic Therapy of Hypoxic Tumor
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Preparation of Ce6-P/W NE
2.3. Characterization
2.4. Singlet Oxygen (1O2) Production in Response to Ultrasound or Light
2.5. Cell Culture
2.6. SDT Efficacy
2.7. PDT Efficacy
2.8. Cytocompatibility
2.9. Comparison between SDT and PDT on Tissue Penetration
3. Results and Discussion
3.1. Preparation and Characterization of an Oxygen-Carrying Photo-Sonotherapeutic (Ce6-P/W NE)
3.2. 1O2 Generation in Response to Ultrasound and Light Excitation
3.3. Enhanced SDT Efficacy
3.4. Enhanced PDT Efficacy
3.5. Cytocompatibility
3.6. Tissue-Penetrating Ability of SDT Compared with PDT
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Hong, L.; Pliss, A.M.; Zhan, Y.; Zheng, W.; Xia, J.; Liu, L.; Qu, J.; Prasad, P.N. Perfluoropolyether Nanoemulsion Encapsulating Chlorin e6 for Sonodynamic and Photodynamic Therapy of Hypoxic Tumor. Nanomaterials 2020, 10, 2058. https://doi.org/10.3390/nano10102058
Hong L, Pliss AM, Zhan Y, Zheng W, Xia J, Liu L, Qu J, Prasad PN. Perfluoropolyether Nanoemulsion Encapsulating Chlorin e6 for Sonodynamic and Photodynamic Therapy of Hypoxic Tumor. Nanomaterials. 2020; 10(10):2058. https://doi.org/10.3390/nano10102058
Chicago/Turabian StyleHong, Liang, Artem M. Pliss, Ye Zhan, Wenhan Zheng, Jun Xia, Liwei Liu, Junle Qu, and Paras N. Prasad. 2020. "Perfluoropolyether Nanoemulsion Encapsulating Chlorin e6 for Sonodynamic and Photodynamic Therapy of Hypoxic Tumor" Nanomaterials 10, no. 10: 2058. https://doi.org/10.3390/nano10102058