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Article

Effect of TiO2 Nanotube Pore Diameter on Human Mesenchymal Stem Cells and Human Osteoblasts

1
Department of Materials, The University of Manchester, Manchester M13 9PL, UK
2
Department of Mechanical Engineering, University of Bath, Bath BA2 7AY, UK
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(11), 2117; https://doi.org/10.3390/nano10112117
Received: 16 September 2020 / Revised: 13 October 2020 / Accepted: 20 October 2020 / Published: 25 October 2020
(This article belongs to the Special Issue Nanomaterials for Biomedical Applications)
The pore diameter of uniformly structured nanotubes can significantly change the behaviour of cells. Recent studies demonstrated that the activation of integrins is affected not by only the surface chemistry between the cell-material interfaces, but also by the features of surface nanotopography, including nanotube diameter. While research has been carried out in this area, there has yet to be a single systemic study to date that succinctly compares the response of both human stem cells and osteoblasts to a range of TiO2 nanotube pore diameters using controlled experiments in a single laboratory. In this paper, we investigate the influence of surface nanotopography on cellular behaviour and osseointegrative properties through a systemic study involving human mesenchymal stem cells (hMSCs) and human osteoblasts (HOBs) on TiO2 nanotubes of 20 nm, 50 nm and 100 nm pore diameters using in-vitro assessments. This detailed study demonstrates the interrelationship between cellular behaviour and nanotopography, revealing that a 20 nm nanotube pore diameter is preferred by hMSCs for the induction of osteogenic differentiation, while 50 nm nanotubular structures are favourable by HOBs for osteoblastic maturation. View Full-Text
Keywords: nanotube; pore diameter; surface nanotopography; stem cell osteogenesis; osteogenic differentiation; osteoblastic maturation nanotube; pore diameter; surface nanotopography; stem cell osteogenesis; osteogenic differentiation; osteoblastic maturation
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MDPI and ACS Style

Khaw, J.S.; Bowen, C.R.; Cartmell, S.H. Effect of TiO2 Nanotube Pore Diameter on Human Mesenchymal Stem Cells and Human Osteoblasts. Nanomaterials 2020, 10, 2117. https://doi.org/10.3390/nano10112117

AMA Style

Khaw JS, Bowen CR, Cartmell SH. Effect of TiO2 Nanotube Pore Diameter on Human Mesenchymal Stem Cells and Human Osteoblasts. Nanomaterials. 2020; 10(11):2117. https://doi.org/10.3390/nano10112117

Chicago/Turabian Style

Khaw, Juan S., Christopher R. Bowen, and Sarah H. Cartmell 2020. "Effect of TiO2 Nanotube Pore Diameter on Human Mesenchymal Stem Cells and Human Osteoblasts" Nanomaterials 10, no. 11: 2117. https://doi.org/10.3390/nano10112117

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