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Communication

Spontaneous Self-Assembly of Single-Chain Amphiphilic Polymeric Nanoparticles in Water

1
Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 10607, Taiwan
2
Advanced Membrane Materials Research Center, National Taiwan University of Science and Technology, Taipei 10607, Taiwan
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(10), 2006; https://doi.org/10.3390/nano10102006
Received: 22 September 2020 / Revised: 7 October 2020 / Accepted: 8 October 2020 / Published: 12 October 2020
(This article belongs to the Special Issue Functional Polymeric Nanoparticles)
Single-chain polymeric nanoparticles (SCPNs) have great potential as functional nanocarriers for drug delivery and bioimaging, but synthetic challenges in terms of final yield and purification procedures limit their use. A new concept to modify and improve the synthetic procedures used to generate water-soluble SCPNs through amphiphilic interactions has been successfully exploited. We developed a new ultrahigh molecular weight amphiphilic polymer containing a hydrophobic poly(epichlorohydrin) backbone and hydrophilic poly(ethylene glycol) side chains. The polymer spontaneously self-assembles into SCPNs in aqueous solution and does not require subsequent purification. The resulting SCPNs possess a number of distinct physical properties, including a uniform hydrodynamic nanoparticle diameter of 10–15 nm, extremely low viscosity and a desirable spherical-like morphology. Concentration-dependent studies demonstrated that stable SCPNs were formed at high concentrations up to 10 mg/mL in aqueous solution, with no significant increase in solution viscosity. Importantly, the SCPNs exhibited high structural stability in media containing serum or phosphate-buffered saline and showed almost no change in hydrodynamic diameter. The combination of these characteristics within a water-soluble SCPN is highly desirable and could potentially be applied in a wide range of biomedical fields. Thus, these findings provide a path towards a new, innovative route for the development of water-soluble SCPNs. View Full-Text
Keywords: amphiphilic interactions; amphiphilic polymers; spontaneous self-assembly; ultrahigh molecular weight; water-soluble single-chain polymeric nanoparticles amphiphilic interactions; amphiphilic polymers; spontaneous self-assembly; ultrahigh molecular weight; water-soluble single-chain polymeric nanoparticles
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MDPI and ACS Style

Huang, S.-Y.; Cheng, C.-C. Spontaneous Self-Assembly of Single-Chain Amphiphilic Polymeric Nanoparticles in Water. Nanomaterials 2020, 10, 2006. https://doi.org/10.3390/nano10102006

AMA Style

Huang S-Y, Cheng C-C. Spontaneous Self-Assembly of Single-Chain Amphiphilic Polymeric Nanoparticles in Water. Nanomaterials. 2020; 10(10):2006. https://doi.org/10.3390/nano10102006

Chicago/Turabian Style

Huang, Shan-You, and Chih-Chia Cheng. 2020. "Spontaneous Self-Assembly of Single-Chain Amphiphilic Polymeric Nanoparticles in Water" Nanomaterials 10, no. 10: 2006. https://doi.org/10.3390/nano10102006

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