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Volume 17
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10.3390/jfb17070330
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Partially Demineralized Acellular Bovine Bone Matrix Supports for Bone Healing In Vivo

by
Cuc Bui
1,2,
Quan Minh To
3,4,
My Thi Ngoc Nguyen
3,4,5,
Thuan Minh Le
6,
Triet Minh Tran
6,
Lam Nguyen Le
1,
Duc Hoang Minh Bui
1,
Lam Van Nguyen
1 and
Ha Le Bao Tran
3,4,5,*
1
Faculty of Odonto—Stomatology, Can Tho University of Medicine and Pharmacy, Can Tho 900000, Vietnam
2
Asian Cosmetic Dentistry, Ho Chi Minh City 700000, Vietnam
3
Faculty of Biology and Biotechnology, University of Science, Ho Chi Minh City 700000, Vietnam
4
Vietnam National University, Ho Chi Minh City 700000, Vietnam
5
Laboratory of Tissue Engineering and Biomedical Materials, University of Science, Ho Chi Minh City 700000, Vietnam
6
Cantho Central General Hospital, Can Tho 900000, Vietnam
*
Author to whom correspondence should be addressed.
J. Funct. Biomater. 2026, 17(7), 330; https://doi.org/10.3390/jfb17070330
Submission received: 29 April 2026 / Revised: 15 June 2026 / Accepted: 18 June 2026 / Published: 6 July 2026
(This article belongs to the Special Issue Biomaterials for Wound Healing and Tissue Repair)
Versions Notes

Abstract

Acellular bone matrix, with its natural extracellular matrix components, has been considered a potential alternative platform for bone grafting. Our study focused on fabricating acellular bovine bone matrix (ABBM) and evaluating its in vitro characteristics and in vivo effect on bone repair. The bovine cancellous bone was subjected to ABBM preparation, which included partial demineralization and decellularization processing. The effects of the ABBM on human bone marrow-derived stem cells (hBMSCs) were evaluated, including viability, migration, attachment, and proliferation. A rabbit bone defect model was implanted with ABBM and histologically assessed for bone healing. The acellular properties were determined by the absence of nuclear material and the accepted minimum residual DNA content. An in vitro study indicated the ABBM’s positive effect on the migration of hBMSCs. ABBM was also demonstrated to support hBMSC attachment and proliferation. In vivo testing was performed in rabbits with a cranial bone defect, which showed complete bone healing after 8 weeks of grafting with ABBM. Overall, the fabricated ABBM demonstrated in vitro and in vivo biocompatibility and effective support for bone healing in vivo, and therefore represents a potential xenogeneic biomaterial for bone tissue repair.
Keywords: decellularization; demineralization; bone matrix; bone healing; osteoconductive; osteoinductive decellularization; demineralization; bone matrix; bone healing; osteoconductive; osteoinductive

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MDPI and ACS Style

Bui, C.; To, Q.M.; Nguyen, M.T.N.; Le, T.M.; Tran, T.M.; Le, L.N.; Bui, D.H.M.; Nguyen, L.V.; Tran, H.L.B. Partially Demineralized Acellular Bovine Bone Matrix Supports for Bone Healing In Vivo. J. Funct. Biomater. 2026, 17, 330. https://doi.org/10.3390/jfb17070330

AMA Style

Bui C, To QM, Nguyen MTN, Le TM, Tran TM, Le LN, Bui DHM, Nguyen LV, Tran HLB. Partially Demineralized Acellular Bovine Bone Matrix Supports for Bone Healing In Vivo. Journal of Functional Biomaterials. 2026; 17(7):330. https://doi.org/10.3390/jfb17070330

Chicago/Turabian Style

Bui, Cuc, Quan Minh To, My Thi Ngoc Nguyen, Thuan Minh Le, Triet Minh Tran, Lam Nguyen Le, Duc Hoang Minh Bui, Lam Van Nguyen, and Ha Le Bao Tran. 2026. "Partially Demineralized Acellular Bovine Bone Matrix Supports for Bone Healing In Vivo" Journal of Functional Biomaterials 17, no. 7: 330. https://doi.org/10.3390/jfb17070330

APA Style

Bui, C., To, Q. M., Nguyen, M. T. N., Le, T. M., Tran, T. M., Le, L. N., Bui, D. H. M., Nguyen, L. V., & Tran, H. L. B. (2026). Partially Demineralized Acellular Bovine Bone Matrix Supports for Bone Healing In Vivo. Journal of Functional Biomaterials, 17(7), 330. https://doi.org/10.3390/jfb17070330

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