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Volume 15
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Article

Effect of Silica Nanoparticle Treatment on Adhesion between Tissue-like Substrates and In Vivo Skin Wound Sealing

by
Yeji Jeon
1,
Tae Ryeol Kim
1,
Eun Seo Park
1,
Jae Hyun Park
2,
Han Sung Youn
2,
Dae Youn Hwang
1,* and
Sungbaek Seo
1,*
1
Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, Miryang 50463, Republic of Korea
2
Young Chemical Co., Ltd., 80-93, Golden root-ro, Juchon-myeon, Gimhae 50969, Republic of Korea
*
Authors to whom correspondence should be addressed.
J. Funct. Biomater. 2024, 15(9), 259; https://doi.org/10.3390/jfb15090259
Submission received: 16 July 2024 / Revised: 30 August 2024 / Accepted: 3 September 2024 / Published: 9 September 2024
(This article belongs to the Special Issue Application of Biomaterials in Tissue Engineering and Regenerative Medicine)
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Abstract

Silica nanoparticles are innovative solutions of surgical glue that can readily adhere to various tissue-like substrates without the need for time-consuming chemical reactions or ultraviolet irradiation. Herein, 10 nm-sized silica nanoparticle (SiNP10) treatment exhibited maximum adhesion strength in the porcine heart tissue model, which was approximately 7.15 times higher than that of the control group of non-treatment. We assessed the effects of silica nanoparticle treatment on in vivo skin wounds by scoring tissue adhesion and inflammation using histological images. Compared to the commercial cyanoacrylate skin adhesive (Dermabond), suppression of inflammatory cytokine levels in the incision wound skin was observed. We further quantified the expression of angiogenic growth factors and connective tissue formation-related proteins. On day 5 after wound closing treatment, the expression levels of PDGF-BB growth factor were significantly higher in SiNP10 treatment (0.64 ± 0.03) compared to Dermabond (0.07 ± 0.05). This stimulated angiogenesis and connective tissue formation in the skin of the incision wound may be associated with the promoting effects of SiNP10 treatment on wound closure and tissue adhesion.
Keywords: inflammation; silica nanoparticles; surgical glue; tissue adhesion; wound healing inflammation; silica nanoparticles; surgical glue; tissue adhesion; wound healing

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MDPI and ACS Style

Jeon, Y.; Kim, T.R.; Park, E.S.; Park, J.H.; Youn, H.S.; Hwang, D.Y.; Seo, S. Effect of Silica Nanoparticle Treatment on Adhesion between Tissue-like Substrates and In Vivo Skin Wound Sealing. J. Funct. Biomater. 2024, 15, 259. https://doi.org/10.3390/jfb15090259

AMA Style

Jeon Y, Kim TR, Park ES, Park JH, Youn HS, Hwang DY, Seo S. Effect of Silica Nanoparticle Treatment on Adhesion between Tissue-like Substrates and In Vivo Skin Wound Sealing. Journal of Functional Biomaterials. 2024; 15(9):259. https://doi.org/10.3390/jfb15090259

Chicago/Turabian Style

Jeon, Yeji, Tae Ryeol Kim, Eun Seo Park, Jae Hyun Park, Han Sung Youn, Dae Youn Hwang, and Sungbaek Seo. 2024. "Effect of Silica Nanoparticle Treatment on Adhesion between Tissue-like Substrates and In Vivo Skin Wound Sealing" Journal of Functional Biomaterials 15, no. 9: 259. https://doi.org/10.3390/jfb15090259

APA Style

Jeon, Y., Kim, T. R., Park, E. S., Park, J. H., Youn, H. S., Hwang, D. Y., & Seo, S. (2024). Effect of Silica Nanoparticle Treatment on Adhesion between Tissue-like Substrates and In Vivo Skin Wound Sealing. Journal of Functional Biomaterials, 15(9), 259. https://doi.org/10.3390/jfb15090259

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