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Article

Clinical and Biochemical Evaluation of the Use of Alb-PRF versus L-PRF in Mandibular Third Molar Extractions: A Split-Mouth Randomized Clinical Trial

by
Kayvon Javid
1,
Carlos Fernando Mourão
2,*,
Rafael Coutinho Mello-Machado
3,
Suelen Cristina Sartoretto
4,
Madelaine Torres
1,
Emanuelle Stellet Lourenço
1,
Paulo Emilio Correa Leite
5,
José Mauro Granjeiro
4,
Gutemberg Gomes Alves
6 and
Monica Diuana Calasans-Maia
4
1
Graduate Program in Dentistry, Fluminense Federal University, Niterói 24020-140, Brazil
2
Department of Periodontology, Tufts University School of Dental Medicine, Boston, MA 02111, USA
3
Department of Implant Dentistry, Universidade Iguaçu, Nova Iguaçu 26260-045, Brazil
4
Department of Oral Surgery, Fluminense Federal University, Niterói 24020-140, Brazil
5
Clinical Research Unit, Antonio Pedro Hospital, Fluminense Federal University, Niterói 24033-900, Brazil
6
Department of Biotechnology, Fluminense Federal University, Niterói 24033-900, Brazil
*
Author to whom correspondence should be addressed.
J. Funct. Biomater. 2023, 14(10), 505; https://doi.org/10.3390/jfb14100505
Submission received: 13 September 2023 / Revised: 29 September 2023 / Accepted: 8 October 2023 / Published: 10 October 2023
(This article belongs to the Special Issue Dentistry: Clinical Applications and Innovative Techniques of New Biomaterials)
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Abstract

Bone tissue engineering seeks biomaterials that enable cell migration, angiogenesis, matrix deposition, and tissue regeneration. Blood concentrates like platelet-rich fibrin (L-PRF) offer a cost-effective source of cells and growth factors to enhance healing. The present study aimed to evaluate heated serum albumin with liquid PRF (Alb-PRF) and L-PRF clinically and biochemically after placement in dental sockets following mandibular third molar extraction. In a controlled, split-mouth study involving 10 volunteers, 20 extracted molars were treated with either Alb-PRF or L-PRF. Post-extraction, pain, trismus, infection presence, and swelling were measured. The concentrations of different analytes in the surgical sites were also examined. The data were statistically analyzed, with significance defined at p < 0.05 (t-test). No significant difference was noted between the groups for pain and trismus, but Alb-PRF showed a significant reduction in swelling on day seven. The Alb-PRF group showed lower levels of pro-inflammatory cytokines (GM-CSF, IL-1b, IL-6, IFNy, IL-8, IL-15, RANTES, and MIP-1a) after seven days, with only higher expressions of MIP-1b, IL-1b, and MCP-1 found in the L-PRF group. Differences were observed in the release of analytes between L-PRF and Alb-PRF, with Alb-PRF significantly reducing edema after seven days. Alb-PRF reduced edema, while L-PRF increased inflammatory cytokines. When compared to L-PRF, Alb-PRF reduced edema and the release of inflammatory cytokines, suggesting promising effects in socket healing while underscoring the role of growth factors and cytokines in potential applications of blood concentrates.
Keywords: platelet-rich fibrin; albumin; lower third molars; L-PRF; Alb-PRF platelet-rich fibrin; albumin; lower third molars; L-PRF; Alb-PRF

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MDPI and ACS Style

Javid, K.; Mourão, C.F.; Mello-Machado, R.C.; Sartoretto, S.C.; Torres, M.; Stellet Lourenço, E.; Leite, P.E.C.; Granjeiro, J.M.; Alves, G.G.; Calasans-Maia, M.D. Clinical and Biochemical Evaluation of the Use of Alb-PRF versus L-PRF in Mandibular Third Molar Extractions: A Split-Mouth Randomized Clinical Trial. J. Funct. Biomater. 2023, 14, 505. https://doi.org/10.3390/jfb14100505

AMA Style

Javid K, Mourão CF, Mello-Machado RC, Sartoretto SC, Torres M, Stellet Lourenço E, Leite PEC, Granjeiro JM, Alves GG, Calasans-Maia MD. Clinical and Biochemical Evaluation of the Use of Alb-PRF versus L-PRF in Mandibular Third Molar Extractions: A Split-Mouth Randomized Clinical Trial. Journal of Functional Biomaterials. 2023; 14(10):505. https://doi.org/10.3390/jfb14100505

Chicago/Turabian Style

Javid, Kayvon, Carlos Fernando Mourão, Rafael Coutinho Mello-Machado, Suelen Cristina Sartoretto, Madelaine Torres, Emanuelle Stellet Lourenço, Paulo Emilio Correa Leite, José Mauro Granjeiro, Gutemberg Gomes Alves, and Monica Diuana Calasans-Maia. 2023. "Clinical and Biochemical Evaluation of the Use of Alb-PRF versus L-PRF in Mandibular Third Molar Extractions: A Split-Mouth Randomized Clinical Trial" Journal of Functional Biomaterials 14, no. 10: 505. https://doi.org/10.3390/jfb14100505

APA Style

Javid, K., Mourão, C. F., Mello-Machado, R. C., Sartoretto, S. C., Torres, M., Stellet Lourenço, E., Leite, P. E. C., Granjeiro, J. M., Alves, G. G., & Calasans-Maia, M. D. (2023). Clinical and Biochemical Evaluation of the Use of Alb-PRF versus L-PRF in Mandibular Third Molar Extractions: A Split-Mouth Randomized Clinical Trial. Journal of Functional Biomaterials, 14(10), 505. https://doi.org/10.3390/jfb14100505

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