Melatonin: An Overview on the Synthesis Processes and on Its Multiple Bioactive Roles Played in Animals and Humans

Andronachi, Vasile-Cosmin; Simeanu, Cristina; Matei, Mădălina; Radu-Rusu, Răzvan-Mihail; Simeanu, Daniel

doi:10.3390/agriculture15030273

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Melatonin: An Overview on the Synthesis Processes and on Its Multiple Bioactive Roles Played in Animals and Humans

by

Vasile-Cosmin Andronachi

,

Cristina Simeanu

^*,

Mădălina Matei

,

Răzvan-Mihail Radu-Rusu

and

Daniel Simeanu

“Ion Ionescu de la Brad” University of Life Sciences, 3 Mihail Sadoveanu Alley, 700489 Iasi, Romania

^*

Author to whom correspondence should be addressed.

Agriculture 2025, 15(3), 273; https://doi.org/10.3390/agriculture15030273

Submission received: 20 December 2024 / Revised: 20 January 2025 / Accepted: 24 January 2025 / Published: 27 January 2025

(This article belongs to the Special Issue Farming Factors’ Influence on Animal Productions)

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Abstract

Melatonin is a natural hormone synthesized mainly by the pineal gland of vertebrates, and, secondarily, by other tissues and organs as well. It is deemed a bioactive molecule due to the multiple roles and functions it performs in animals and humans. Research conducted up to 2024 has reported the presence of melatonin in a wide variety of plants and bacteria, as well. This review aims to collect some of the scientific data to identify and describe the main sources of melatonin, and to document the functions and roles it plays in animal organisms. It also includes a description of the main technological and nutritional factors that can positively or negatively influence the synthesis and secretion process of melatonin, which is subsequently transported from the animal body into some food products, such as milk. This paper also includes information on the interaction between melatonin and other bioactive compounds present in animal and human bodies, with the aim of identifying what other functions and roles this hormone performs, and whether it interacts with other substances present in the vertebrate organism.

Keywords: melatonin; pineal gland; bioactive molecule; nutritional factors; technological factors

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MDPI and ACS Style

Andronachi, V.-C.; Simeanu, C.; Matei, M.; Radu-Rusu, R.-M.; Simeanu, D. Melatonin: An Overview on the Synthesis Processes and on Its Multiple Bioactive Roles Played in Animals and Humans. Agriculture 2025, 15, 273. https://doi.org/10.3390/agriculture15030273

AMA Style

Andronachi V-C, Simeanu C, Matei M, Radu-Rusu R-M, Simeanu D. Melatonin: An Overview on the Synthesis Processes and on Its Multiple Bioactive Roles Played in Animals and Humans. Agriculture. 2025; 15(3):273. https://doi.org/10.3390/agriculture15030273

Chicago/Turabian Style

Andronachi, Vasile-Cosmin, Cristina Simeanu, Mădălina Matei, Răzvan-Mihail Radu-Rusu, and Daniel Simeanu. 2025. "Melatonin: An Overview on the Synthesis Processes and on Its Multiple Bioactive Roles Played in Animals and Humans" Agriculture 15, no. 3: 273. https://doi.org/10.3390/agriculture15030273

APA Style

Andronachi, V.-C., Simeanu, C., Matei, M., Radu-Rusu, R.-M., & Simeanu, D. (2025). Melatonin: An Overview on the Synthesis Processes and on Its Multiple Bioactive Roles Played in Animals and Humans. Agriculture, 15(3), 273. https://doi.org/10.3390/agriculture15030273

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Melatonin: An Overview on the Synthesis Processes and on Its Multiple Bioactive Roles Played in Animals and Humans

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