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Agriculture
Volume 11
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10.3390/agriculture11010068
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Article

Antiarthritic Potential of Calotropis procera Leaf Fractions in FCA-Induced Arthritic Rats: Involvement of Cellular Inflammatory Mediators and Other Biomarkers

by
Vandana S. Singh
1,
Shashikant C. Dhawale
1,
Faiyaz Shakeel
2,
Md. Faiyazuddin
3,4 and
Sultan Alshehri
2,*
1
School of Pharmacy, S.R.T.M. University, Nanded 431606, Maharashtra, India
2
Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
3
School of Pharmacy, Alkarim University, Katihar 854106, Bihar, India
4
Nano Drug Delivery®, Raleigh-Durham, NC 27705, USA
*
Author to whom correspondence should be addressed.
Agriculture 2021, 11(1), 68; https://doi.org/10.3390/agriculture11010068
Submission received: 5 December 2020 / Revised: 11 January 2021 / Accepted: 12 January 2021 / Published: 15 January 2021
(This article belongs to the Special Issue Medicinal and Aromatic Plants in Agricultural Research When Considering Criteria of Multifunctionality and Sustainability)
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Abstract

Calotropis procera (commonly known as Swallow wort) is described in the Ayurvedic literature for the treatment of inflammation and arthritic disorders. Therefore, in the present work, the antiarthritic activity of potential fractions of Swallow wort leaf was evaluated and compared with standards (indomethacin and ibuprofen). This study was designed in Wistar rats for the investigation of antiarthritic activity and acute toxicity of Swallow wort. Arthritis was induced in Wistar rats by injecting 0.1 mL of Freund’s complete adjuvant (FCA) on the 1st and 7th days subcutaneously into the subplantar region of the left hind paw. Evaluation of our experimental findings suggested that antiarthritic activity of methanol fraction of Swallow wort (MFCP) was greater than ethyl acetate fraction of Swallow wort (EAFCP), equal to standard ibuprofen, and slightly lower than standard indomethacin. MFCP significantly reduced paw edema on the 17th, 21st, 24th, and 28th days. It also showed significant effect (p < 0.01) on arthritic score, paw withdrawal latency, and body weight. The inhibition of serum lysosomal enzymes and proinflammatory cytokines along with improvement of radiographic features of hind legs was also recorded with MFCP. Finally, it was concluded that MFCP can be a feasible therapeutic candidate for the treatment of inflammatory arthritis.
Keywords: Calotropis procera leaves; chronic inflammatory model; cytokines; Freund’s complete adjuvant; indomethacin Calotropis procera leaves; chronic inflammatory model; cytokines; Freund’s complete adjuvant; indomethacin

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MDPI and ACS Style

Singh, V.S.; Dhawale, S.C.; Shakeel, F.; Faiyazuddin, M.; Alshehri, S. Antiarthritic Potential of Calotropis procera Leaf Fractions in FCA-Induced Arthritic Rats: Involvement of Cellular Inflammatory Mediators and Other Biomarkers. Agriculture 2021, 11, 68. https://doi.org/10.3390/agriculture11010068

AMA Style

Singh VS, Dhawale SC, Shakeel F, Faiyazuddin M, Alshehri S. Antiarthritic Potential of Calotropis procera Leaf Fractions in FCA-Induced Arthritic Rats: Involvement of Cellular Inflammatory Mediators and Other Biomarkers. Agriculture. 2021; 11(1):68. https://doi.org/10.3390/agriculture11010068

Chicago/Turabian Style

Singh, Vandana S., Shashikant C. Dhawale, Faiyaz Shakeel, Md. Faiyazuddin, and Sultan Alshehri. 2021. "Antiarthritic Potential of Calotropis procera Leaf Fractions in FCA-Induced Arthritic Rats: Involvement of Cellular Inflammatory Mediators and Other Biomarkers" Agriculture 11, no. 1: 68. https://doi.org/10.3390/agriculture11010068

APA Style

Singh, V. S., Dhawale, S. C., Shakeel, F., Faiyazuddin, M., & Alshehri, S. (2021). Antiarthritic Potential of Calotropis procera Leaf Fractions in FCA-Induced Arthritic Rats: Involvement of Cellular Inflammatory Mediators and Other Biomarkers. Agriculture, 11(1), 68. https://doi.org/10.3390/agriculture11010068

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