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Current and Future Trends in Molecular Biomarkers for Diagnostic, Prognostic, and Predictive Purposes in Non-Melanoma Skin Cancer
Review

Recent Advances in Signaling Pathways Comprehension as Carcinogenesis Triggers in Basal Cell Carcinoma

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Department of Dermatology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania
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Department of Dermatology, “Victor Babes” Clinical Hospital for Infectious Diseases, 030303 Bucharest, Romania
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Department of Microbiology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania
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Department of Physiology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania
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Immunology Department, “Victor Babes” National Institute of Pathology, 050096 Bucharest, Romania
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Colentina Clinical Hospital, 020125 Bucharest, Romania
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Faculty of Biology, University of Bucharest, 76201 Bucharest, Romania
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Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(9), 3010; https://doi.org/10.3390/jcm9093010
Received: 18 July 2020 / Revised: 7 September 2020 / Accepted: 16 September 2020 / Published: 18 September 2020
(This article belongs to the Special Issue Current Advances on Non-Melanoma Skin Cancer)
Basal cell carcinoma (BCC) is the most common malignant skin tumor. BCC displays a different behavior compared with other neoplasms, has a slow evolution, and metastasizes very rarely, but sometimes it causes an important local destruction. Chronic ultraviolet exposure along with genetic factors are the most important risk factors involved in BCC development. Mutations in the PTCH1 gene are associated with Gorlin syndrome, an autosomal dominant disorder characterized by the occurrence of multiple BCCs, but are also the most frequent mutations observed in sporadic BCCs. PTCH1 encodes for PTCH1 protein, the most important negative regulator of the Hedgehog (Hh) pathway. There are numerous studies confirming Hh pathway involvement in BCC pathogenesis. Although Hh pathway has been intensively investigated, it remains incompletely elucidated. Recent studies on BCC tumorigenesis have shown that in addition to Hh pathway, there are other signaling pathways involved in BCC development. In this review, we present recent advances in BCC carcinogenesis. View Full-Text
Keywords: basal cell carcinoma; Hedgehog pathway; signaling pathways; carcinogenesis basal cell carcinoma; Hedgehog pathway; signaling pathways; carcinogenesis
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MDPI and ACS Style

Tampa, M.; Georgescu, S.R.; Mitran, C.I.; Mitran, M.I.; Matei, C.; Scheau, C.; Constantin, C.; Neagu, M. Recent Advances in Signaling Pathways Comprehension as Carcinogenesis Triggers in Basal Cell Carcinoma. J. Clin. Med. 2020, 9, 3010. https://doi.org/10.3390/jcm9093010

AMA Style

Tampa M, Georgescu SR, Mitran CI, Mitran MI, Matei C, Scheau C, Constantin C, Neagu M. Recent Advances in Signaling Pathways Comprehension as Carcinogenesis Triggers in Basal Cell Carcinoma. Journal of Clinical Medicine. 2020; 9(9):3010. https://doi.org/10.3390/jcm9093010

Chicago/Turabian Style

Tampa, Mircea, Simona R. Georgescu, Cristina I. Mitran, Madalina I. Mitran, Clara Matei, Cristian Scheau, Carolina Constantin, and Monica Neagu. 2020. "Recent Advances in Signaling Pathways Comprehension as Carcinogenesis Triggers in Basal Cell Carcinoma" Journal of Clinical Medicine 9, no. 9: 3010. https://doi.org/10.3390/jcm9093010

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