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Open AccessArticle

Seven Years Leptospirosis Follow-Up in a Critical Care Unit of a French Metropolitan Hospital; Role of Real Time PCR for a Quick and Acute Diagnosis

1
Service de Bactériologie-Virologie, CHRU de Tours, 37044 Tours, France
2
Service de Médecine Intensive Réanimation, INSERM CIC 1415, CRICS-TriggerSep Research Network, F37044 Tours, France
3
UMR1282 Infectiologie et Santé Publique, INRA-Université de Tours, F-37380 Nouzilly, France
4
Centre d’étude des pathologies respiratoires, INSERM U1100, Université de Tours, F37000 Tours, France
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(9), 3011; https://doi.org/10.3390/jcm9093011
Received: 18 August 2020 / Revised: 4 September 2020 / Accepted: 8 September 2020 / Published: 18 September 2020
(This article belongs to the Section Emergency Medicine)
(1) Background: Leptospirosis infection can lead to multiple organ failure, requiring hospitalization in an intensive care unit for supportive care, along with initiation of an adapted antibiotic therapy. Achieving a quick diagnosis is decisive in the management of these patients. (2) Methods: We present here a review of leptospirosis cases diagnosed in the intensive care unit of our hospital over seven years. Clinical and biological data were gathered, and we compared the differences in terms of diagnostic method. (3) Results: Molecular biology method by Polymerase Chain Reaction (PCR) allowed quick and reliable diagnosis when performed in the first days after the symptoms began. Moreover, we identified that sampling blood and urine for PCR was more efficient than performing PCR on only one type of biological sample. (4) Conclusions: Our results confirm the efficiency of PCR for the quick diagnosis of leptospirosis and suggest that testing both blood and urine early in the disease might improve diagnosis. View Full-Text
Keywords: leptospirosis; intensive care unit; polymerase chain reaction; diagnosis leptospirosis; intensive care unit; polymerase chain reaction; diagnosis
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MDPI and ACS Style

Bahuaud, O.; Pastuszka, A.; Le Brun, C.; Ehrmann, S.; Lanotte, P. Seven Years Leptospirosis Follow-Up in a Critical Care Unit of a French Metropolitan Hospital; Role of Real Time PCR for a Quick and Acute Diagnosis. J. Clin. Med. 2020, 9, 3011.

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