Timing of Osteoporotic Vertebral Fractures in Lung and Heart Transplantation: A Longitudinal Study
Abstract
:1. Introduction
- To evaluate the prevalence of osteoporosis and fragility fractures in a population of adults before and after receiving a heart or lung transplant.
- To elucidate any factors which may influence fractures in heart or lung transplantation subjects.
2. Materials and Methods
Statistical Analysis
3. Results
4. Discussion
Author Contributions
Funding
Conflicts of Interest
References
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Parameters | Lung Recipients | Heart Recipients | ||||
---|---|---|---|---|---|---|
Pre-Transplantation (n = 128) | Post-Transplantation (n = 113) | Follow Up (n = 34) | Pre-Trapnsplantation (n = 85) | Post-Transplantation (n = 73) | Follow Up (n = 41) | |
Age (y) | 50.7 ± 11.8 | 52.9 ± 11.7 | 55.2 ± 13.5 | 51.1 ± 10.4 | 53.9 ± 10.3 | 56.9 ± 10.5 |
Weight (kg) | 69.8 ± 15.1 | 70.9 ± 15.4 | 69.4 ± 11.7 | 73.7 ± 10.1 | 74.9 ± 11.9 | 72.9 ± 11.3 |
Height (cm) | 168.1 ± 7.8 ° | 165.9 ± 16.1 * | 167.7 ± 6.6 ^ | 172.8 ± 9.4 | 172.0 ± 8.1 | 169.3 ± 7.2 |
BMI (kg/m2) | 24.7 ± 4.7 | 24.9 ± 4.4 | 24.6 ± 3.6 | 24.5 ± 2.9 | 25.4 ± 3.9 | 25.9 ± 3.9 |
Calcium (mg/dL) | 9.2 ± 0.5 | 9.1 ± 0.6 | 9.3 ± 0.4 | 9.1 ± 0.7 | 9.4 ± 0.6 | 9.2 ± 0.5 |
Phosphorus (mg/dL) | 3.5 ± 0.6 | 3.6 ± 0.7 | 3.4 ± 0.7 | 3.5 ± 0.6 | 3.3 ± 0.6 | 3.3 ± 0.5 |
Creatinine (mg/dL) | 0.9 ± 0.2 °° | 1.3 ± 0.5 ** | 1.3 ± 0.5 §§ | 1.2 ± 0.3 | 1.3 ± 0.4 | 1.4 ± 0.5 |
Alkaline phosphatase (UI/L) | 80.5 ± 48.3 | 72.8 ± 36.7 | 71.1 ± 29.6 | 90.5 ± 31.2 | 85.2 ± 39.1 | 73.2 ± 21.4 |
25OHD (ng/mL) | 19.1 ± 11.8 | 21.6 ± 9.9 | 21.2 ± 9.3 | 22.4 ± 14.7 | 19.9 ± 14.6 | 23.8 ± 13.6 |
PTH (pg/mL) | 42.7. ± 14.7 | 56.0 ± 46.1 | 57.8 ± 24.3 | 46.2 ± 35.2 | 76.9 ± 29.5 | 71.8 ± 39.6 |
LS-BMD (g/cm2) | 1.011 ± 0.182 | 1.000 ± 0.194 | 1.025 ± 0.177 §,^ | 0.988 ± 0.151 | 0.982 ± 0.155 | 0.964 ± 0.210 § ^ |
FN-BMD (g/cm2) | 0.839 ± 0.167 | 0.765 ± 0.162 ** | 0.767 ± 0.121 § | 0.797 ± 0.140 | 0.779 ± 0.134 | 0.728 ± 0.135 ^ |
TH-BMD (g/cm2) | 0.863 ± 0.172 | 0.818 ± 0.157 ** | 0.819 ± 0.138 § | 0.838 ± 0.112 | 0.811 ± 0.126 * | 0.798 ± 0.102 ^ |
Variable | Undestandardized Coefficient, b | 95%CI | p |
---|---|---|---|
Lung | |||
Vertebral fracture | |||
Age | 0.018 | 0.006 to 0.029 | 0.003 |
TH-BMD | −1.421 | −2.284 to −0.558 | 0.002 |
History of fracture | 0.382 | 0.003 to 0.760 | 0.048 |
Heart | |||
Vertebral fracture | |||
History of fracture | 0.867 | 0.510 to 1.224 | <0.01 |
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Caffarelli, C.; Tomai Pitinca, M.D.; Alessandri, M.; Cameli, P.; Bargagli, E.; Bennett, D.; Fossi, A.; Bernazzali, S.; Gonnelli, S. Timing of Osteoporotic Vertebral Fractures in Lung and Heart Transplantation: A Longitudinal Study. J. Clin. Med. 2020, 9, 2941. https://doi.org/10.3390/jcm9092941
Caffarelli C, Tomai Pitinca MD, Alessandri M, Cameli P, Bargagli E, Bennett D, Fossi A, Bernazzali S, Gonnelli S. Timing of Osteoporotic Vertebral Fractures in Lung and Heart Transplantation: A Longitudinal Study. Journal of Clinical Medicine. 2020; 9(9):2941. https://doi.org/10.3390/jcm9092941
Chicago/Turabian StyleCaffarelli, Carla, Maria D. Tomai Pitinca, Mario Alessandri, Paolo Cameli, Elena Bargagli, David Bennett, Antonella Fossi, Sonia Bernazzali, and Stefano Gonnelli. 2020. "Timing of Osteoporotic Vertebral Fractures in Lung and Heart Transplantation: A Longitudinal Study" Journal of Clinical Medicine 9, no. 9: 2941. https://doi.org/10.3390/jcm9092941