Anosmia and Ageusia as Predictive Signs of COVID-19 in Healthcare Workers in Italy: A Prospective Case-Control Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Setting
2.2. Data Collection
2.3. Specimen Collection and Laboratory Test
2.4. Data Analysis
3. Results
4. Discussion
Limitations
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Variables | Controls n (%) or Mean (SD) | Cases n (%) or Mean (SD) | p |
---|---|---|---|
Sex | 0.03 | ||
Female | 52 (69.3) | 14 (46.7) | |
Male | 23 (30.7) | 16 (53.3) | |
Age | 43.6 (12.9) | 40.7 (12.9) | 0.294 |
Type of profession | 0.066 | ||
Physicians | 24 (32) | 12 (40) | |
Residents | 20 (26.7) | 12 (40) | |
Nurses | 21 (28) | 2 (6.7) | |
Other healthcare professional | 9 (12) | 2 (6.7) | |
Administrative staff | 1 (1.3) | 2 (6.7) | |
Ward | 0.004 | ||
Medicine | 38 (50.7) | 26 (86.7) | |
Surgery | 15 (20) | 0 (0) | |
Emergency/intensive care | 10 (13.3) | 1 (3.3) | |
Diagnostics | 12 (16) | 3 (10) |
Variables | Controls | Cases | p |
---|---|---|---|
Fever | 0.160 | ||
No | 31 (41.3%) | 8 (26.7%) | |
Yes | 44 (58.7%) | 22 (73.3%) | |
Cough | 0.665 | ||
No | 35 (46.7%) | 12 (40.0%) | |
Yes | 40 (53.3%) | 18 (60.0%) | |
Dyspnea | 0.036 | ||
No | 74 (98.7%) | 27 (90.0%) | |
Yes | 1 (1.3%) | 3 (10.0%) | |
Pharyngodynia | <0.001 | ||
No | 47 (62.7%) | 29 (96.7%) | |
Yes | 28 (37.3%) | 1 (3.3%) | |
Asthenia | 0.246 | ||
No | 56 (74.7%) | 19 (63.3%) | |
Yes | 19 (25.3%) | 11 (36.7%) | |
Headache | 0.023 | ||
No | 57 (78.1%) | 16 (21.9%) | |
Yes | 18 (56.3%) | 14 (43.8%) | |
Anosmia | <0.001 | ||
No | 70 (93.3%) | 16 (53.3%) | |
Yes | 5 (6.7%) | 14 (46.7%) | |
Myalgia/arthralgia | 0.838 | ||
No | 54 (72.0%) | 21 (70.0%) | |
Yes | 21 (28.0%) | 9 (30.0%) | |
Diarrhea | 0.741 | ||
No | 69 (93.0%) | 27 (90.0%) | |
Yes | 6 (7.0%) | 3 (10.0%) | |
Thoracic pain | 0.506 | ||
No | 70 (93.3%) | 29 (96.7%) | |
Yes | 5 (6.7%) | 1 (3.3%) | |
Conjunctivitis | 0.190 | ||
No | 69 (93.0%) | 25 (83.3%) | |
Yes | 6 (7.0%) | 5 (16.7%) | |
Rhinitis | 0.345 | ||
No | 62 (82.7%) | 27 (90.0%) | |
Yes | 13 (17.3%) | 3 (10.0%) | |
Ageusia | <0.001 | ||
No | 69 (93.0%) | 18 (60.0%) | |
Yes | 6 (7.0%) | 12 (40.0%) | |
Anosmia + Fever | <0.001 | ||
No | 72 (96%) | 19 (63.3%) | |
Yes | 3 (4%) | 11 (36.7%) | |
Anosmia + other respiratory symptoms | 0.001 | ||
No | 71 (94.7%) | 21 (70%) | |
Yes | 4 (5.3%) | 9 (30%) | |
Isolated anosmia | 0.286 | ||
No | 75 (100%) | 29 (96.7) | |
Yes | 0 (0%) | 1 (3.3) | |
Anosmia + Dyspnea | <0.001 | ||
No | 69 (92%) | 13 (43.3%) | |
Yes | 6 (8%) | 17 (56.7%) | |
Anosmia + Ageusia | <0.001 | ||
No | 72 (96%) | 18 (60%) | |
Yes | 3 (4%) | 12 (40%) |
Symptom | Sensitivity | Specificity | Positive Predictive Value | Negative Predictive Value | AUC | Adj OR (95% CI) |
---|---|---|---|---|---|---|
Fever | 73.3 | 41.3 | 33.3 | 79.5 | 0.573 | 2.22 (0.83–5.90) |
Cough | 60.0 | 46.7 | 31.0 | 74.5 | 0.533 | 1.30 (0.52–3.24) |
Dyspnea | 10.0 | 98.7 | 75 | 73.27 | 0.543 | 9.83 (0.90–107.22) |
Pharyngodynia | 3.3 | 62.7 | 3.4 | 61.8 | 0.330 | 0.05 (0.01–0.41) |
Asthenia | 36.7 | 74.7 | 36.66 | 74.66 | 0.557 | 1.85 (0.71–4.81) |
Headache | 46.7 | 76.0 | 43.75 | 78.08 | 0.736 | 3.916 (1.45–10.56) |
Anosmia | 46.7 | 93.3 | 73.7 | 81.4 | 0.700 | 14.75 (4.27–50.87) |
Myalgia/arthralgia | 30.0 | 72.0 | 30.0 | 72.0 | 0.510 | 1.02 (0.39–2.70) |
Diarrhea | 10.0 | 20.0 | 33.33 | 71.88 | 0.510 | 1.19 (0.27–5.26) |
Thoracic pain | 3.3 | 93.3 | 16.7 | 70.7 | 0.483 | 0.56 (0.06–5.33) |
Conjunctivitis | 16.7 | 20.0 | 45.45 | 73.40 | 0.543 | 2.40 (0.64–8.94) |
Rhinitis | 10.0 | 82.7 | 18.75 | 30.34 | 0.583 | 0.55 (0.14–2.17) |
Ageusia | 40.0 | 92.0 | 66.7 | 79.3 | 0.660 | 9.18 (2.80–30.15) |
Anosmia + fever | 36.7 | 96 | 78.6 | 79.1 | 0.663 | 19.70 (4.5–86.8) |
Anosmia + other respiratory symptoms | 30 | 94.7 | 69.2 | 77.2 | 0.623 | 6.87 (1.87–25.21) |
Isolated anosmia | 3.3 | 100 | 100 | 72.1 | 0.517 | not determined |
Anosmia + dyspnea | 56.7 | 92 | 73.9 | 84.1 | 0.743 | 18.78 (5.66–63.35) |
Anosmia + ageusia | 40 | 97.3 | 85.7 | 80.2 | 0.687 | 30.65 (5.78–162.6) |
Number of Symptoms | Controls | Cases | Adj OR (95% CI) |
---|---|---|---|
<2 | 15 (20%) | 4 (13.3%) | 0.49 (0.14–1.74) |
≥2 | 60 (80%) | 26 (86.7%) | 2.03 (0.57–7.17) |
≥3 | 35 (50%) | 22 (73.3%) | 3.18 (1.22–8.28) |
≥4 | 16 (21.3%) | 18 (60%) | 5.89 (2.25–15.42) |
≥5 | 4 (5.3%) | 6 (20%) | 6.04 (1.46–24.93) |
6 | 1 (1.3%) | 3 (10%) | 9.93 (0.94–104.4) |
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La Torre, G.; Massetti, A.P.; Antonelli, G.; Fimiani, C.; Fantini, M.; Marte, M.; Faticoni, A.; Previte, C.M.; Turriziani, O.; Pugliese, F.; et al. Anosmia and Ageusia as Predictive Signs of COVID-19 in Healthcare Workers in Italy: A Prospective Case-Control Study. J. Clin. Med. 2020, 9, 2870. https://doi.org/10.3390/jcm9092870
La Torre G, Massetti AP, Antonelli G, Fimiani C, Fantini M, Marte M, Faticoni A, Previte CM, Turriziani O, Pugliese F, et al. Anosmia and Ageusia as Predictive Signs of COVID-19 in Healthcare Workers in Italy: A Prospective Case-Control Study. Journal of Clinical Medicine. 2020; 9(9):2870. https://doi.org/10.3390/jcm9092870
Chicago/Turabian StyleLa Torre, Giuseppe, Anna Paola Massetti, Guido Antonelli, Caterina Fimiani, Mauro Fantini, Mattia Marte, Augusto Faticoni, Carlo Maria Previte, Ombretta Turriziani, Francesco Pugliese, and et al. 2020. "Anosmia and Ageusia as Predictive Signs of COVID-19 in Healthcare Workers in Italy: A Prospective Case-Control Study" Journal of Clinical Medicine 9, no. 9: 2870. https://doi.org/10.3390/jcm9092870