Neural Networks to Predict Radiographic Brain Injury in Pediatric Patients Treated with Extracorporeal Membrane Oxygenation

Shah, Neel; Farhat, Abdelaziz; Tweed, Jefferson; Wang, Ziheng; Lee, Jeon; McBeth, Rafe; Skinner, Michael; Tian, Fenghua; Thiagarajan, Ravi; Raman, Lakshmi

doi:10.3390/jcm9092718

Submit to this Journal Review for this Journal Edit a Special Issue

Article Menu

...

Open AccessArticle

Neural Networks to Predict Radiographic Brain Injury in Pediatric Patients Treated with Extracorporeal Membrane Oxygenation

²,

³,

⁴

⁵

⁶,

⁷,

⁸,

⁹ and

^3,10,*

Department of Pediatrics, Division of Pediatric Critical Care, Washington University School of Medicine, St. Louis, MO 63110, USA

Department of Pediatrics, Pediatrix Medical Group, Orem, UT 84057, USA

Children’s Health Dallas, Dallas, TX 75201, USA

⁴

Department of Mechanical Engineering, The University of Texas at Dallas, Dallas, TX 75080, USA

⁵

Department of Bioinformatics, University of Texas Southwestern, Dallas, TX 75390, USA

⁶

Department of Radiation Oncology, University of Texas Southwestern, Dallas, TX 75390, USA

⁷

Department of Computer Science, The University of Texas at Dallas, Dallas, TX 75080, USA

⁸

Department of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA

⁹

Department of Cardiology, Boston Children’s Hospital, Boston, MA 02115, USA

¹⁰

Department of Pediatrics, Division of Pediatric Critical Care, University of Texas Southwestern, Dallas, TX 75390, USA

Author to whom correspondence should be addressed.

J. Clin. Med. 2020, 9(9), 2718; https://doi.org/10.3390/jcm9092718

Received: 15 July 2020 / Revised: 7 August 2020 / Accepted: 19 August 2020 / Published: 22 August 2020

(This article belongs to the Special Issue Extracorporeal Life Support during Cardiac Arrest and Cardiogenic Shock)

View Full-Text Download PDF

Browse Figures

Citation Export

Abstract

Brain injury is a significant source of morbidity and mortality for pediatric patients treated with Extracorporeal Membrane Oxygenation (ECMO). Our objective was to utilize neural networks to predict radiographic evidence of brain injury in pediatric ECMO-supported patients and identify specific variables that can be explored for future research. Data from 174 ECMO-supported patients were collected up to 24 h prior to, and for the duration of, the ECMO course. Thirty-five variables were collected, including physiological data, markers of end-organ perfusion, acid-base homeostasis, vasoactive infusions, markers of coagulation, and ECMO-machine factors. The primary outcome was the presence of radiologic evidence of moderate to severe brain injury as established by brain CT or MRI. This information was analyzed by a neural network, and results were compared to a logistic regression model as well as clinician judgement. The neural network model was able to predict brain injury with an Area Under the Curve (AUC) of 0.76, 73% sensitivity, and 80% specificity. Logistic regression had 62% sensitivity and 61% specificity. Clinician judgment had 39% sensitivity and 69% specificity. Sequential feature group masking demonstrated a relatively greater contribution of physiological data and minor contribution of coagulation factors to the model's performance. These findings lay the foundation for further areas of research directions. View Full-Text

Keywords: ECMO; neurologic injury; brain injury; machine learning; neural networks; pediatrics

▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Share and Cite

MDPI and ACS Style

Shah, N.; Farhat, A.; Tweed, J.; Wang, Z.; Lee, J.; McBeth, R.; Skinner, M.; Tian, F.; Thiagarajan, R.; Raman, L. Neural Networks to Predict Radiographic Brain Injury in Pediatric Patients Treated with Extracorporeal Membrane Oxygenation. J. Clin. Med. 2020, 9, 2718. https://doi.org/10.3390/jcm9092718

AMA Style

Shah N, Farhat A, Tweed J, Wang Z, Lee J, McBeth R, Skinner M, Tian F, Thiagarajan R, Raman L. Neural Networks to Predict Radiographic Brain Injury in Pediatric Patients Treated with Extracorporeal Membrane Oxygenation. Journal of Clinical Medicine. 2020; 9(9):2718. https://doi.org/10.3390/jcm9092718

Chicago/Turabian Style

Shah, Neel, Abdelaziz Farhat, Jefferson Tweed, Ziheng Wang, Jeon Lee, Rafe McBeth, Michael Skinner, Fenghua Tian, Ravi Thiagarajan, and Lakshmi Raman. 2020. "Neural Networks to Predict Radiographic Brain Injury in Pediatric Patients Treated with Extracorporeal Membrane Oxygenation" Journal of Clinical Medicine 9, no. 9: 2718. https://doi.org/10.3390/jcm9092718

Find Other Styles

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Abstract views Pdf views Html views

Article Menu

Neural Networks to Predict Radiographic Brain Injury in Pediatric Patients Treated with Extracorporeal Membrane Oxygenation

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Article Access Map by Country/Region

Further Information

Guidelines

MDPI Initiatives

Follow MDPI