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Article

Distinct Microbiota Dysbiosis in Patients with Non-Erosive Reflux Disease and Esophageal Adenocarcinoma

by
Jerry Zhou
1,*,
Prapti Shrestha
1,
Zhiguang Qiu
2,
David G. Harman
1,
Wun-Chung Teoh
3,
Sam Al-Sohaily
1,3,
Han Liem
4,
Ian Turner
1,3 and
Vincent Ho
1,3
1
School of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia
2
Hawkesbury Institute for the Environment, Western Sydney University, Penrith, NSW 2750, Australia
3
Department of Gastroenterology, Campbelltown Hospital, Campbelltown, NSW 2560, Australia
4
Nepean Hospital, Kingswood, NSW 2747, Australia
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(7), 2162; https://doi.org/10.3390/jcm9072162
Submission received: 4 June 2020 / Revised: 3 July 2020 / Accepted: 6 July 2020 / Published: 8 July 2020
(This article belongs to the Special Issue Gastrointestinal Disorders: Diagnosis, Treatments and Clinical Features)
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Abstract

Non-erosive reflux disease (NERD) and esophageal adenocarcinoma (EAC) are often regarded as bookends in the gastroesophageal reflux disease spectrum. However, there is limited clinical evidence to support this disease paradigm while the underlying mechanisms of disease progression remain unclear. In this study, we used 16S rRNA sequencing and mass-spectrometer-based proteomics to characterize the esophageal microbiota and host mucosa proteome, respectively. A total of 70 participants from four patient groups (NERD, reflux esophagitis, Barrett’s esophagus, and EAC) and a control group were analyzed. Our results showed a unique NERD microbiota composition, distinct to control and other groups. We speculate that an increase in sulfate-reducing Proteobacteria and Bacteroidetes along with hydrogen producer Dorea are associated with a mechanistic role in visceral hypersensitivity. We also observed a distinct EAC microbiota consisting of a high abundance of lactic acid-producing bacteria (Staphylococcus, Lactobacillus, Bifidobacterium, and Streptococcus), which may contribute towards carcinogenesis through dysregulated lactate metabolism. This study suggests the close relationship between esophageal mucosal microbiota and the appearance of pathologies of this organ.
Keywords: microbiome; gastroesophageal reflux disease; proteome; non-erosive reflux disease; esophageal adenocarcinoma; Barrett’s esophagus; reflux esophagitis microbiome; gastroesophageal reflux disease; proteome; non-erosive reflux disease; esophageal adenocarcinoma; Barrett’s esophagus; reflux esophagitis

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MDPI and ACS Style

Zhou, J.; Shrestha, P.; Qiu, Z.; Harman, D.G.; Teoh, W.-C.; Al-Sohaily, S.; Liem, H.; Turner, I.; Ho, V. Distinct Microbiota Dysbiosis in Patients with Non-Erosive Reflux Disease and Esophageal Adenocarcinoma. J. Clin. Med. 2020, 9, 2162. https://doi.org/10.3390/jcm9072162

AMA Style

Zhou J, Shrestha P, Qiu Z, Harman DG, Teoh W-C, Al-Sohaily S, Liem H, Turner I, Ho V. Distinct Microbiota Dysbiosis in Patients with Non-Erosive Reflux Disease and Esophageal Adenocarcinoma. Journal of Clinical Medicine. 2020; 9(7):2162. https://doi.org/10.3390/jcm9072162

Chicago/Turabian Style

Zhou, Jerry, Prapti Shrestha, Zhiguang Qiu, David G. Harman, Wun-Chung Teoh, Sam Al-Sohaily, Han Liem, Ian Turner, and Vincent Ho. 2020. "Distinct Microbiota Dysbiosis in Patients with Non-Erosive Reflux Disease and Esophageal Adenocarcinoma" Journal of Clinical Medicine 9, no. 7: 2162. https://doi.org/10.3390/jcm9072162

APA Style

Zhou, J., Shrestha, P., Qiu, Z., Harman, D. G., Teoh, W.-C., Al-Sohaily, S., Liem, H., Turner, I., & Ho, V. (2020). Distinct Microbiota Dysbiosis in Patients with Non-Erosive Reflux Disease and Esophageal Adenocarcinoma. Journal of Clinical Medicine, 9(7), 2162. https://doi.org/10.3390/jcm9072162

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