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Gut Microbiota: Implications in Alzheimer’s Disease

Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Institute of Neuroscience, Key Laboratory of Molecular Neurobiology of the Ministry of Education, Second Military Medical University, Shanghai 200433, China
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(7), 2042;
Received: 30 March 2020 / Revised: 16 May 2020 / Accepted: 15 June 2020 / Published: 29 June 2020
Alzheimer’s disease (AD), the most common cause of dementia, is a neurodegenerative disease that seriously threatens human health and life quality. The main pathological features of AD include the widespread deposition of amyloid-beta and neurofibrillary tangles in the brain. So far, the pathogenesis of AD remains elusive, and no radical treatment has been developed. In recent years, mounting evidence has shown that there is a bidirectional interaction between the gut and brain, known as the brain–gut axis, and that the intestinal microbiota are closely related to the occurrence and development of neurodegenerative diseases. In this review, we will summarize the laboratory and clinical evidence of the correlation between intestinal flora and AD, discuss its possible role in the pathogenesis, and prospect its applications in the diagnosis and treatment of AD. View Full-Text
Keywords: Alzheimer’s disease; gut microbiota; microbiota–gut–brain axis; neurodegenerative disease; intestinal flora Alzheimer’s disease; gut microbiota; microbiota–gut–brain axis; neurodegenerative disease; intestinal flora
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He, Y.; Li, B.; Sun, D.; Chen, S. Gut Microbiota: Implications in Alzheimer’s Disease. J. Clin. Med. 2020, 9, 2042.

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