Next Article in Journal
Burden of Undiagnosed Type 2 Diabetes in Diabetic Kidney Disease: A Japanese Retrospective Cohort Study
Previous Article in Journal
Clinical-Forensic Autopsy Findings to Defeat COVID-19 Disease: A Literature Review
Open AccessArticle

The Complex Relationship Between Serum Uric Acid, Endothelial Function and Small Vessel Remodeling in Humans

1
Department of Clinical and Experimental Medicine, University of Pisa, 56124 Pisa, Italy
2
National Centre for Cardiovascular Prevention and Outcomes, Institute of Cardiovascular Science, University College London, London EC1A 4NP, UK
3
Department of Twin Research & Genetic Epidemiology, King’s College London, London WC2R 2LS, UK
4
School of Biomedical Engineering and Imaging Sciences, King’s College London, London WC2R 2LS, UK
5
Department of Clinical Therapeutics, National and Kapodistrian University of Athens, 10679 Athens, Greece
6
Department of Statistics, Athens University of Economics and Business, 10434 Athens, Greece
7
Department of Biostatistics and Research Support, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
8
Fourth Unit of Internal Medicine, University Hospital of Pisa, 56124 Pisa, Italy
9
Cardiology Unit, Fondazione Istituto Auxologico Italiano, Ospedale S. Luca, IRCCS Istituto Auxologico Italiano, 20149 Milan, Italy
10
Department of Clinical and Experimental Sciences, University of Brescia, 25121 Brescia, Italy
11
Department of Medical and Surgical Science, Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy
12
Clinica Medica, Deptartment of Health Science, University Milano-Bicocca, 20126 Milan, Italy
13
Division of Medicine, Spedali Civili di Brescia, Montichiari Hospital, 25018 Brescia, Italy
*
Author to whom correspondence should be addressed.
These authors equally contributed to the manuscript.
Name and affiliations of the study group members are reported in the acknowledgements.
J. Clin. Med. 2020, 9(7), 2027; https://doi.org/10.3390/jcm9072027
Received: 29 May 2020 / Revised: 24 June 2020 / Accepted: 24 June 2020 / Published: 28 June 2020
(This article belongs to the Section Vascular Medicine)
Aims: The relationship between serum uric acid (SUA) and microvascular remodeling in humans remains largely unexplored. We assessed whether SUA provides additional information on the severity of microvascular remodeling than that obtained from the European Heart Score (HS), the patterns of microvascular remodeling associated with changes in SUA levels and the mediation by endothelial function and nitric oxide (NO) availability on this relationship. Methods: A total of 162 patients included in the microvascular dataset of the Italian Society of Hypertension with available information on SUA, media-to-lumen (M/L) ratio, media cross-sectional area (MCSA), endothelial function, NO availability and HS were included in the analysis. The top tertile of M/L ratio and MCSA were used to define severe microvascular remodeling. Results: A U-shaped association was observed between SUA and both M/L ratio and MCSA. Adjustment for HS did not affect these associations. SUA was able to reclassify a significant number of subjects without, and with, severe M/L ratio and MCSA remodeling over the HS alone. The microvascular remodeling associated with SUA levels presented a predominant hypertrophic pattern. SUA was inversely associated with endothelial function and NO availability. Structural equation modeling analysis controlling for the HS suggested that the association of SUA with M/L ratio and MCSA was mediated through changes in endothelial function and NO availability. Conclusions: The addition of SUA to the HS improves the identification of subjects with greater microvascular remodeling. The relationship between SUA and microvascular remodeling is mediated by endothelial function and NO availability. View Full-Text
Keywords: uric acid; microvascular; remodeling; endothelial function uric acid; microvascular; remodeling; endothelial function
Show Figures

Figure 1

MDPI and ACS Style

Masi, S.; Georgiopoulos, G.; Alexopoulos, G.; Pateras, K.; Rosada, J.; Seravalle, G.; De Ciuceis, C.; Taddei, S.; Borghi, C.; Grassi, G.; Rizzoni, D.; Virdis, A.; the Study Groups on the Uric Acid Right for heArt Health (URRAH); Micro-and Macro-circulation of the Italian Society of Hypertension (SIIA). The Complex Relationship Between Serum Uric Acid, Endothelial Function and Small Vessel Remodeling in Humans. J. Clin. Med. 2020, 9, 2027.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop