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Endothelin-1 Serum Concentration is Lower in Children and Adolescents with High Myopia, a Preliminary Study
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To Correct or Not Correct? Actual Evidence, Controversy and the Questions That Remain Open

1
Carl Zeiss Vision International GmbH, ZEISS Group, Turnstrasse 27, 73430 Aalen, Germany
2
Ophthalmic Research Institute, Elfriede-Aulhorn-Straße 7, 72076 Tuebingen, Germany
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(6), 1975; https://doi.org/10.3390/jcm9061975
Received: 31 May 2020 / Revised: 19 June 2020 / Accepted: 23 June 2020 / Published: 24 June 2020
(This article belongs to the Special Issue New Frontiers in Myopia Progression in Children)
Clinical studies and basic research have attempted to establish a relationship between myopia progression and single vision spectacle wear, albeit with unclear results. Single vision spectacle lenses are continuously used as the control group in myopia control trials. Hence, it is a matter of high relevance to investigate further whether they yield any shift on the refractive state, which could have been masked by being used as a control. In this review, eye development in relation to eyes fully corrected versus those under-corrected is discussed, and new guidelines are provided for the analysis of structural eye changes due to optical treatments. These guidelines are tested and optimised, while ethical implications are revisited. This newly described methodology can be translated to larger clinical trials, finally exerting the real effect of full correction via single vision spectacle lens wear on eye growth and myopia progression. View Full-Text
Keywords: myopia; under-correction; spectacles; eye growth; short-sightedness; near-sightedness; vision myopia; under-correction; spectacles; eye growth; short-sightedness; near-sightedness; vision
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García García, M.; Breher, K.; Ohlendorf, A.; Wahl, S. To Correct or Not Correct? Actual Evidence, Controversy and the Questions That Remain Open. J. Clin. Med. 2020, 9, 1975.

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