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Article

Relationships between Pulmonary Hypertension Risk, Clinical Profiles, and Outcomes in Dilated Cardiomyopathy

1
Department of Cardiac and Vascular Diseases, Jagiellonian University Collegium Medicum, John Paul II Hospital, 31-202 Krakow, Poland
2
Students’ Scientific Group at Department of Cardiac and Vascular Diseases, Jagiellonian University Collegium Medicum, John Paul II Hospital, 31-202 Krakow, Poland
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(6), 1660; https://doi.org/10.3390/jcm9061660
Received: 7 May 2020 / Revised: 28 May 2020 / Accepted: 28 May 2020 / Published: 1 June 2020
Pulmonary hypertension (PH) in patients with heart failure (HF) contributes to a poorer prognosis. However, in those with dilated cardiomyopathy (DCM), the true prevalence and role of PH is unclear. Therefore, this study aimed to analyze the profile of DCM patients at various levels of PH risk, determined via echocardiography, and its impact on outcomes. The 502 DCM in- and out-patient records were retrospectively analyzed. Information on patient status was gathered after 45.9 ± 31.3 months. Patients were divided into 3 PH-risk groups based on results from echocardiography measurements: low (L, n = 239, 47.6%), intermediate (I, n = 153, 30.5%), and high (H, n = 110, 21.9%). Symptom duration, atrial fibrillation, ventricular tachyarrhythmia, ejection fraction, right atrial area, and moderate or severe mitral regurgitation were found to be independently associated with PH risk. During the follow-up period, 83 (16.5%) DCM patients died: 29 (12.1%) in L, 31 (20.3%) in I, and 23 (20.9%) in H. L-patients had a significantly lower risk of all-cause death (L to H: HR 0.55 (95%CI 0.32–0.98), p = 0.01), while no differences in prognosis were found between I and H. In conclusion, over one in five DCM patients had a high PH risk, and low PH risk was associated with better prognoses. View Full-Text
Keywords: pulmonary hypertension risk; echocardiography; dilated cardiomyopathy pulmonary hypertension risk; echocardiography; dilated cardiomyopathy
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MDPI and ACS Style

Dziewięcka, E.; Wiśniowska-Śmiałek, S.; Karabinowska, A.; Holcman, K.; Gliniak, M.; Winiarczyk, M.; Karapetyan, A.; Kaciczak, M.; Podolec, P.; Kostkiewicz, M.; Hlawaty, M.; Leśniak-Sobelga, A.; Rubiś, P. Relationships between Pulmonary Hypertension Risk, Clinical Profiles, and Outcomes in Dilated Cardiomyopathy. J. Clin. Med. 2020, 9, 1660. https://doi.org/10.3390/jcm9061660

AMA Style

Dziewięcka E, Wiśniowska-Śmiałek S, Karabinowska A, Holcman K, Gliniak M, Winiarczyk M, Karapetyan A, Kaciczak M, Podolec P, Kostkiewicz M, Hlawaty M, Leśniak-Sobelga A, Rubiś P. Relationships between Pulmonary Hypertension Risk, Clinical Profiles, and Outcomes in Dilated Cardiomyopathy. Journal of Clinical Medicine. 2020; 9(6):1660. https://doi.org/10.3390/jcm9061660

Chicago/Turabian Style

Dziewięcka, Ewa, Sylwia Wiśniowska-Śmiałek, Aleksandra Karabinowska, Katarzyna Holcman, Matylda Gliniak, Mateusz Winiarczyk, Arman Karapetyan, Monika Kaciczak, Piotr Podolec, Magdalena Kostkiewicz, Marta Hlawaty, Agata Leśniak-Sobelga, and Paweł Rubiś. 2020. "Relationships between Pulmonary Hypertension Risk, Clinical Profiles, and Outcomes in Dilated Cardiomyopathy" Journal of Clinical Medicine 9, no. 6: 1660. https://doi.org/10.3390/jcm9061660

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