The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3.6-Year Prospective Study from a Referral Center of Interstitial Lung Disease and Lung Transplantation †

Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, 39011 Santander, Spain

Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, 39008 Santander, Spain

Department of Pneumology, Hospital Universitario Marqués de Valdecilla, 39008 Santander, Spain

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Department of Radiology, Hospital Universitario Marqués de Valdecilla, 39008 Santander, Spain

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Department of Pathology, Hospital Universitario Marqués de Valdecilla, 39008 Santander, Spain

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School of Medicine, Universidad de Cantabria, 39011 Santander, Spain

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Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa

Author to whom correspondence should be addressed.

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The results of this work were partially presented at the 2019 ACR Meeting in Atlanta, GA, USA (abstract no. 2155) (View Abstract and Citation Information Online- https://acrabstracts.org/abstract/the-spectrum-of-interstitial-lung-disease-associated-with-autoimmune-diseases-data-of-a-3-year-prospective-study-from-a-referral-center-of-lung-transplantation/).

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Belén Atienza-Mateo and Sara Remuzgo-Martínez shared first authorship.

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Miguel A. González-Gay and José M. Cifrián shared senior authorship.

J. Clin. Med. 2020, 9(6), 1606; https://doi.org/10.3390/jcm9061606

Received: 19 April 2020 / Revised: 21 May 2020 / Accepted: 22 May 2020 / Published: 26 May 2020

(This article belongs to the Special Issue Diagnosis, Clinical Features and Management of Interstitial Lung Diseases in Rheumatic Disorders)

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Abstract

Interstitial lung disease (ILD) may occur in patients with a rheumatic autoimmune disease (AD), increasing their risk of morbidity and mortality. However, little is known about the prevalence of AD in patients diagnosed with an ILD. In this prospective study, we determined the spectrum of ILD associated with AD (AD-ILD) among patients sent for assessment to a single clinic of ILD and lung transplantation from a referral center between May 2016 and December 2019. ILD diagnosis was made by pneumologists based on clinical and radiological findings and pulmonary function test abnormalities. All patients with ILD were also assessed by experienced rheumatologists. During the period of assessment, 338 patients were diagnosed with ILD. Among them, 32.8% fulfilled definitions for an AD. Most cases with AD-ILD had a diagnosis of rheumatoid arthritis (27.0%), systemic sclerosis (26.1%) or anti-synthetase syndrome (17.1%). Interestingly, 18% of the patients with AD-ILD were diagnosed as having an interstitial pneumonia with autoimmune features. Antinuclear antibodies and non-specific interstitial pneumonia were the most frequent positive autoantibodies and radiological pattern found in AD-ILD patients, respectively. In conclusion, our study indicates that a high number of ILD patients have a related AD. Consequently, close collaboration among rheumatologists and pneumologists is needed. View Full-Text

Keywords: interstitial lung disease; rheumatic autoimmune diseases; connective tissue diseases; interstitial pneumonia with autoimmune features

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MDPI and ACS Style

Atienza-Mateo, B.; Remuzgo-Martínez, S.; Mora Cuesta, V.M.; Iturbe-Fernández, D.; Fernández-Rozas, S.; Prieto-Peña, D.; Calderón-Goercke, M.; Corrales, A.; Blanco Rodríguez, G.; Gómez-Román, J.J.; González-Gay, M.Á.; Cifrián, J.M. The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3.6-Year Prospective Study from a Referral Center of Interstitial Lung Disease and Lung Transplantation ^†. J. Clin. Med. 2020, 9, 1606. https://doi.org/10.3390/jcm9061606

AMA Style

Atienza-Mateo B, Remuzgo-Martínez S, Mora Cuesta VM, Iturbe-Fernández D, Fernández-Rozas S, Prieto-Peña D, Calderón-Goercke M, Corrales A, Blanco Rodríguez G, Gómez-Román JJ, González-Gay MÁ, Cifrián JM. The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3.6-Year Prospective Study from a Referral Center of Interstitial Lung Disease and Lung Transplantation ^†. Journal of Clinical Medicine. 2020; 9(6):1606. https://doi.org/10.3390/jcm9061606

Chicago/Turabian Style

Atienza-Mateo, Belén, Sara Remuzgo-Martínez, Víctor M. Mora Cuesta, David Iturbe-Fernández, Sonia Fernández-Rozas, Diana Prieto-Peña, Mónica Calderón-Goercke, Alfonso Corrales, Gerardo Blanco Rodríguez, José J. Gómez-Román, Miguel Á. González-Gay, and José M. Cifrián. 2020. "The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3.6-Year Prospective Study from a Referral Center of Interstitial Lung Disease and Lung Transplantation ^†" Journal of Clinical Medicine 9, no. 6: 1606. https://doi.org/10.3390/jcm9061606

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The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3.6-Year Prospective Study from a Referral Center of Interstitial Lung Disease and Lung Transplantation ^†^†

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The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3.6-Year Prospective Study from a Referral Center of Interstitial Lung Disease and Lung Transplantation ^†^†