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Actual Persistence of Abatacept in Rheumatoid Arthritis: Results of the French-Ric Network

Faculty of Medicine, University of Reims Champagne-Ardenne, EA 3797, 51092 Reims, France
Rheumatology Department, Hôpital Maison Blanche, Reims University Hospital, CEDEX, 51092 Reims, France
CHU Lille, Rheumatology Department, F-59000 Lille, France
Rheumatology Department, Hôpital Nord, University Hospital of Amiens-Picardie, 80000 Amiens, France
Department of Research and Innovation, Robert Debre’ Hospital, Reims University Hospitals, 51092 Reims, France
Rheumatology Department, Bethune Hospital Center, 62408 Bethune, France
Rheumatology Department, Hôpital Victor Provo, Hospital of Roubaix, 59100 Roubaix, France
Rheumatology Department, Hôpital Saint Philibert, Hospital of Lomme, 59160 Lomme, France
Rheumatology, Medical Office, Boulevard du Dr Schweitzer, 02100 Saint-Quentin, France
Rheumatology Department, Institut François Calot, 62600 Berck-Sur-Mer, France
Department of Rheumatology, Valenciennes Hospital Center, 59300 Valenciennes, France
Rheumatology, Medical Office, 39 Quai des Mines, 59300 Valenciennes, France
Department of Rheumatology, Poitiers University Hospital, 86021 Poitiers, France
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(5), 1528;
Received: 9 April 2020 / Revised: 28 April 2020 / Accepted: 15 May 2020 / Published: 19 May 2020
(This article belongs to the Special Issue Rheumatoid Arthritis: Pathogenesis, Diagnosis and Therapies)
Objectives: Data on abatacept (ABA) persistence in routine practice are limited. We aimed to study ABA persistence rates at 12 months, according to the date of initiation, and to analyze the factors associated with persistence at 12 months. Methods: We performed an observational, ambispective, multi-center study from January 2008 to July 2016, based on the French-RIC Network. We defined three groups of patients followed up for rheumatoid arthritis (RA), according to the date of initiation of ABA therapy: Group 1 (from 2007 to 31 July 2010: ABA indicated after anti-TNF failure); Group 2 (from 1 August 2010 to 31 March 2014: ABA indicated after conventional antirheumatic drugs failure); Group 3 (from 1 April 2014 to 1 July 2016: ABA available by the subcutaneous injection). Results: Among 517 patients who initiated ABA, drug persistence at 12 months was 68%. The only factor significantly associated with persistence rate at 12 months was C-reactive protein (CRP) < 10 mg/L at ABA initiation (odds ratio (OR) 0.6, 95% confidence interval 0.3–0.9; p = 0.0016). There was no significant difference in drug persistence according to date of initiation, the line of biological disease-modifying antirheumatic drugs (bDMARD) therapy or the route of administration. Conclusions: In routine practice, over time, ABA has come to be initiated earlier in the course of therapy for RA in France. Abatacept persistence is similar to that reported in the Orencia Rheumatoid Arthritis (ORA) registry, and does not differ according to the date of initiation. The only factor found to be associated with the persistence rate at 12 months was CRP < 10 mg/L at ABA initiation. View Full-Text
Keywords: rheumatoid arthritis; abatacept; persistence rheumatoid arthritis; abatacept; persistence
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Salmon, J.-H.; Letarouilly, J.-G.; Goëb, V.; Kanagaratnam, L.; Coquerelle, P.; Guyot, M.-H.; Houvenagel, E.; Lecuyer, N.; Marguerie, L.; Morel, G.; Baudens, G.; Gervais, E.; Flipo, R.-M. Actual Persistence of Abatacept in Rheumatoid Arthritis: Results of the French-Ric Network. J. Clin. Med. 2020, 9, 1528.

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