Next Article in Journal
Plasma Hyperosmolality Prolongs QTc Interval and Increases Risk for Atrial Fibrillation in Traumatic Brain Injury Patients
Next Article in Special Issue
Eating Disorders, Heredity and Environmental Activation: Getting Epigenetic Concepts into Practice
Previous Article in Journal
Visual Feedback and Postural Control in Multiple Sclerosis
Previous Article in Special Issue
Prevalence and Associated Factors of Nocturnal Eating Behavior and Sleep-Related Eating Disorder-Like Behavior in Japanese Young Adults: Results of an Internet Survey Using Munich Parasomnia Screening
Article

Insular Cell Integrity Markers Linked to Weight Concern in Anorexia Nervosa—An MR-Spectroscopy Study

1
Department of Psychosomatic Medicine and Psychotherapy, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany
2
Department of Psychiatry and Psychotherapy, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany
3
Luzerner Psychiatrie, Hospital St. Urban, 4915 St. Urban, Switzerland
4
Department of Radiology, Medical Physics, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany
5
Department of Psychosomatic Medicine and Psychotherapy, Ortenau Klinikum, Teaching Hospital of University of Freiburg, 77654 Offenburg, Germany
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(5), 1292; https://doi.org/10.3390/jcm9051292
Received: 31 March 2020 / Revised: 27 April 2020 / Accepted: 28 April 2020 / Published: 30 April 2020
(This article belongs to the Special Issue Advances in Eating Disorders)
Objective: An insular involvement in the pathogenesis of anorexia nervosa (AN) has been suggested in many structural and functional neuroimaging studies. This magnetic resonance spectroscopy (MRS) study is the first to investigate metabolic signals in the anterior insular cortex in patients with AN and recovered individuals (REC). Method: The MR spectra of 32 adult women with AN, 21 REC subjects and 33 healthy controls (HC) were quantified for absolute N-acetylaspartate (NAA), glutamate + glutamine (Glx), total choline, myo-inositol, creatine concentrations (mM/L). After adjusting the metabolite concentrations for age and partial gray/white matter volume, group differences were tested using one-way multivariate analyses of variance (MANOVA). Post-hoc analyses of variance were applied to identify those metabolites that showed significant group effects. Correlations were tested for associations with psychometric measures (eating disorder examination), duration of illness, and body mass index. Results: The MANOVA exhibited a significant group effect. The NAA signal was reduced in the AN group compared to the HC group. The REC and the HC groups did not differ in metabolite concentrations. In the AN group, lower NAA and Glx signals were related to increased weight concern. Discussion: We interpret the decreased NAA availability in the anterior insula as a signal of impaired neuronal integrity or density. The association of weight concern, which is a core feature of AN, with decreased NAA and Glx indicates that disturbances of glutamatergic neurotransmission might be related to core psychopathology in AN. The absence of significant metabolic differences between the REC and HC subjects suggests that metabolic alterations in AN represent a state rather than a trait phenomenon. View Full-Text
Keywords: anorexia nervosa; magnetic resonance spectroscopy; MRS; insula; glutamate; N-acetylaspartate; NAA anorexia nervosa; magnetic resonance spectroscopy; MRS; insula; glutamate; N-acetylaspartate; NAA
Show Figures

Figure 1

MDPI and ACS Style

Maier, S.; Nickel, K.; Perlov, E.; Kukies, A.; Zeeck, A.; Tebartz van Elst, L.; Endres, D.; Spieler, D.; Holovics, L.; Hartmann, A.; Dacko, M.; Lange, T.; Joos, A. Insular Cell Integrity Markers Linked to Weight Concern in Anorexia Nervosa—An MR-Spectroscopy Study. J. Clin. Med. 2020, 9, 1292. https://doi.org/10.3390/jcm9051292

AMA Style

Maier S, Nickel K, Perlov E, Kukies A, Zeeck A, Tebartz van Elst L, Endres D, Spieler D, Holovics L, Hartmann A, Dacko M, Lange T, Joos A. Insular Cell Integrity Markers Linked to Weight Concern in Anorexia Nervosa—An MR-Spectroscopy Study. Journal of Clinical Medicine. 2020; 9(5):1292. https://doi.org/10.3390/jcm9051292

Chicago/Turabian Style

Maier, Simon, Kathrin Nickel, Evgeniy Perlov, Alina Kukies, Almut Zeeck, Ludger Tebartz van Elst, Dominique Endres, Derek Spieler, Lukas Holovics, Armin Hartmann, Michael Dacko, Thomas Lange, and Andreas Joos. 2020. "Insular Cell Integrity Markers Linked to Weight Concern in Anorexia Nervosa—An MR-Spectroscopy Study" Journal of Clinical Medicine 9, no. 5: 1292. https://doi.org/10.3390/jcm9051292

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop