Next Article in Journal
Wound Lavage in Studies on Vital Pulp Therapy of Permanent Teeth with Carious Exposures: A Qualitative Systematic Review
Next Article in Special Issue
The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, and Control
Previous Article in Journal
Transforaminal Epidural Balloon Adhesiolysis via a Contralateral Interlaminar Retrograde Foraminal Approach: A Retrospective Analysis and Technical Considerations
Previous Article in Special Issue
People with Suspected COVID-19 Symptoms Were More Likely Depressed and Had Lower Health-Related Quality of Life: The Potential Benefit of Health Literacy

Master Regulator Analysis of the SARS-CoV-2/Human Interactome

Department of Surgical and Medical Science, University of Catanzaro, 88100 Catanzaro, Italy
Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(4), 982;
Received: 28 February 2020 / Revised: 27 March 2020 / Accepted: 28 March 2020 / Published: 1 April 2020
The recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 causing the respiratory tract disease COVID-19 has reached worldwide resonance and a global effort is being undertaken to characterize the molecular features and evolutionary origins of this virus. In this paper, we set out to shed light on the SARS-CoV-2/host receptor recognition, a crucial factor for successful virus infection. Based on the current knowledge of the interactome between SARS-CoV-2 and host cell proteins, we performed Master Regulator Analysis to detect which parts of the human interactome are most affected by the infection. We detected, amongst others, affected apoptotic and mitochondrial mechanisms, and a downregulation of the ACE2 protein receptor, notions that can be used to develop specific therapies against this new virus. View Full-Text
Keywords: coronavirus; bioinformatics; gene network analysis; COVID-19; SARS-CoV-2 coronavirus; bioinformatics; gene network analysis; COVID-19; SARS-CoV-2
Show Figures

Figure 1

MDPI and ACS Style

Guzzi, P.H.; Mercatelli, D.; Ceraolo, C.; Giorgi, F.M. Master Regulator Analysis of the SARS-CoV-2/Human Interactome. J. Clin. Med. 2020, 9, 982.

AMA Style

Guzzi PH, Mercatelli D, Ceraolo C, Giorgi FM. Master Regulator Analysis of the SARS-CoV-2/Human Interactome. Journal of Clinical Medicine. 2020; 9(4):982.

Chicago/Turabian Style

Guzzi, Pietro H., Daniele Mercatelli, Carmine Ceraolo, and Federico M. Giorgi. 2020. "Master Regulator Analysis of the SARS-CoV-2/Human Interactome" Journal of Clinical Medicine 9, no. 4: 982.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop