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Open AccessArticle

Master Regulator Analysis of the SARS-CoV-2/Human Interactome

1
Department of Surgical and Medical Science, University of Catanzaro, 88100 Catanzaro, Italy
2
Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(4), 982; https://doi.org/10.3390/jcm9040982
Received: 28 February 2020 / Revised: 27 March 2020 / Accepted: 28 March 2020 / Published: 1 April 2020
The recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 causing the respiratory tract disease COVID-19 has reached worldwide resonance and a global effort is being undertaken to characterize the molecular features and evolutionary origins of this virus. In this paper, we set out to shed light on the SARS-CoV-2/host receptor recognition, a crucial factor for successful virus infection. Based on the current knowledge of the interactome between SARS-CoV-2 and host cell proteins, we performed Master Regulator Analysis to detect which parts of the human interactome are most affected by the infection. We detected, amongst others, affected apoptotic and mitochondrial mechanisms, and a downregulation of the ACE2 protein receptor, notions that can be used to develop specific therapies against this new virus. View Full-Text
Keywords: coronavirus; bioinformatics; gene network analysis; COVID-19; SARS-CoV-2 coronavirus; bioinformatics; gene network analysis; COVID-19; SARS-CoV-2
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MDPI and ACS Style

Guzzi, P.H.; Mercatelli, D.; Ceraolo, C.; Giorgi, F.M. Master Regulator Analysis of the SARS-CoV-2/Human Interactome. J. Clin. Med. 2020, 9, 982.

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