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Open AccessArticle

The Glucocorticoid Receptor NR3C1 in Testicular Peritubular Cells is Developmentally Regulated and Linked to the Smooth Muscle-Like Cellular Phenotype

1
Biomedical Center, Cell Biology, Anatomy III, Ludwig Maximilian University of Munich, 82152 Planegg-Martinsried, Germany
2
Ibidi GmbH, 82166 Gräfelfing, Germany
3
Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR 97006-248, USA
4
Andrologicum, 80331 Munich, Germany
5
Andrology Center, 81241 Munich, Germany
*
Authors to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(4), 961; https://doi.org/10.3390/jcm9040961
Received: 2 March 2020 / Revised: 24 March 2020 / Accepted: 27 March 2020 / Published: 31 March 2020
(This article belongs to the Special Issue Approach to Male Infertility and Induction of Spermatogenesis)
Whether glucocorticoids (GC) can directly affect human testicular functions is not well understood. A predominant site of GC receptor (GR; NR3C1) expression in the adult testis are peritubular smooth muscle-like cells, which express smooth muscle actin (ACTA2), contract and thereby are involved in sperm transport. In contrast to the adult, neither GR nor ACTA2, or elastin (ELN) were detected in the peritubular compartment before puberty in non-human primate testes. In isolated human testicular peritubular cells (HTPCs), activation of GR by dexamethasone (Dex) caused the translocation of GR to the nucleus and stimulated expression of ACTA2 and ELN, without affecting the expression of collagens. Cytoskeletal ACTA2-rearrangements were observed and were associated with an increased ability to contract. Our results indicate post-pubertal testicular roles of GC in the maintenance of the contractile, smooth muscle-like phenotype of peritubular cells. View Full-Text
Keywords: human male fertility; human testis; dexamethasone; elastin; glucocorticoid; cytoskeleton human male fertility; human testis; dexamethasone; elastin; glucocorticoid; cytoskeleton
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MDPI and ACS Style

Welter, H.; Herrmann, C.; Dellweg, N.; Missel, A.; Thanisch, C.; Urbanski, H.F.; Köhn, F.-M.; Schwarzer, J.U.; Müller-Taubenberger, A.; Mayerhofer, A. The Glucocorticoid Receptor NR3C1 in Testicular Peritubular Cells is Developmentally Regulated and Linked to the Smooth Muscle-Like Cellular Phenotype. J. Clin. Med. 2020, 9, 961. https://doi.org/10.3390/jcm9040961

AMA Style

Welter H, Herrmann C, Dellweg N, Missel A, Thanisch C, Urbanski HF, Köhn F-M, Schwarzer JU, Müller-Taubenberger A, Mayerhofer A. The Glucocorticoid Receptor NR3C1 in Testicular Peritubular Cells is Developmentally Regulated and Linked to the Smooth Muscle-Like Cellular Phenotype. Journal of Clinical Medicine. 2020; 9(4):961. https://doi.org/10.3390/jcm9040961

Chicago/Turabian Style

Welter, Harald; Herrmann, Carola; Dellweg, Nils; Missel, Annika; Thanisch, Christiane; Urbanski, Henryk F.; Köhn, Frank-Michael; Schwarzer, J. U.; Müller-Taubenberger, Annette; Mayerhofer, Artur. 2020. "The Glucocorticoid Receptor NR3C1 in Testicular Peritubular Cells is Developmentally Regulated and Linked to the Smooth Muscle-Like Cellular Phenotype" J. Clin. Med. 9, no. 4: 961. https://doi.org/10.3390/jcm9040961

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