Decreased Glucose Utilization Contributes to Memory Impairment in Patients with Glufosinate Ammonium Intoxication
Abstract
:1. Introduction
2. Methods
2.1. Study Design and Participants
2.2. MRI and FDG-PET Acquisition
2.3. FDG-PET Image Preprocessing and Voxel-Based Single-Subject Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Variables | Values |
---|---|
Male sex, n (%) | 5 (55.6%) |
Age, year | 57 (38–83) |
Hypertension, n (%) | 3 (33.3%) |
Diabetes mellitus, n (%) | 1 (11.1%) |
Depression, n (%) | 2 (22.2%) |
Current smoker, n (%) | 4 (44.4%) |
Alcohol history, bottles/week | 1 (0–14) |
† Ingested volume, mL | 300 (100–500) |
Seizure, n (%) | 7 (77.8%) |
† Initial GCS, score | 9 (3–15) |
† Initial ammonia, mg/dL | 130.6 (69.1–230.0) |
† MMSE (n = 6) | 24.5 (14–28) |
†* Orientation (10) | 8.5 (6–10) |
†* Registration (3) | 3 (0–3) |
†* Attention and Calculation (5) | 3 (0–4) |
†* Recall (3) | 2.5 (0–3) |
†* Language (9) | 9 (6–9) |
† CDR (n = 6) | 0.5 (0–0.5) |
APACHE II score | 20 (6–35) |
Systemic hypotension, n (%) | 6 (66.7%) |
Acute kidney injury, n (%) | 1 (11.1%) |
Mechanical ventilation, n (%) | 7 (77.8%) |
† Hospital day | 12 (6–53) |
† ICU stay day | 6 (3–41) |
No. | FDG-PET Finding | Hospital Stay, Days | ICU Stay, Days | Seizure Duration, Days | F/U Duration, Months | ||
---|---|---|---|---|---|---|---|
Initial | Follow up (I) | Follow up (II) | |||||
1 | Decreased metabolic activity in frontal and temporal lobes | Improved but remained | Improved but remained | 53 | 41 | 6 | 12 |
2 | Decreased metabolic activity in frontal and temporal lobes | Improved | Improved | 6 | 3 | No | 3 |
3 | Decreased metabolic activity in frontal and temporal lobes | Not performed | Not performed | 14 | 7 | 2 | 6 |
4 | Decreased metabolic activity in inferior frontal lobe | Not performed | Not performed | 10 | 6 | 1 | 1 |
5 | Decreased metabolic activity in frontal lobe | Not performed | Not performed | 12 | 4 | 1 | 1 |
6 | Decreased metabolic activity in frontal and temporal lobes | Not performed | Not performed | 24 | 8 | 3 | 2 |
7 | Decreased metabolic activity in frontal and temporal lobes | Not performed | Not performed | 19 | 13 | 3 | 1 |
8 | Decreased metabolic activity in frontal and temporal lobes | Improved | Not performed | 9 | 3 | No | 2 |
9 | Decreased metabolic activity in frontal and temporal lobes | Not performed | Not performed | 11 | 5 | 2 | Loss |
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Park, S.; Kim, J.I.; Cho, N.-j.; Oh, S.W.; Park, J.; Yoo, I.D.; Gil, H.-W.; Lee, S.M. Decreased Glucose Utilization Contributes to Memory Impairment in Patients with Glufosinate Ammonium Intoxication. J. Clin. Med. 2020, 9, 1213. https://doi.org/10.3390/jcm9041213
Park S, Kim JI, Cho N-j, Oh SW, Park J, Yoo ID, Gil H-W, Lee SM. Decreased Glucose Utilization Contributes to Memory Impairment in Patients with Glufosinate Ammonium Intoxication. Journal of Clinical Medicine. 2020; 9(4):1213. https://doi.org/10.3390/jcm9041213
Chicago/Turabian StylePark, Samel, Joong Il Kim, Nam-jun Cho, Se Won Oh, Jongkyu Park, Ik Dong Yoo, Hyo-Wook Gil, and Sang Mi Lee. 2020. "Decreased Glucose Utilization Contributes to Memory Impairment in Patients with Glufosinate Ammonium Intoxication" Journal of Clinical Medicine 9, no. 4: 1213. https://doi.org/10.3390/jcm9041213