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Article

Apical Periodontitis and Diabetes Mellitus Type 2: A Systematic Review and Meta-Analysis

by
Flor de Liz Pérez-Losada
1,
Albert Estrugo-Devesa
1,2,
Lissett Castellanos-Cosano
3,
Juan José Segura-Egea
3,
José López-López
1,2,* and
Eugenio Velasco-Ortega
3
1
Department of Odontostomatology, Faculty of Medicine and Health Sciences (School of Dentistry), University of Barcelona, L’Hospitalet de Llobregat, 08907 Barcelona, Spain
2
Oral Health and Masticatory System Group (Bellvitge Biomedical Research Institute) IDIBELL, University of Barcelona, L’Hospitalet de Llobregat, 08907 Barcelona, Spain
3
Department of Stomatology, School of Dentistry, University of Sevilla, 41009 Sevilla, Spain
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(2), 540; https://doi.org/10.3390/jcm9020540
Submission received: 27 December 2019 / Revised: 6 February 2020 / Accepted: 12 February 2020 / Published: 17 February 2020
(This article belongs to the Special Issue Oral Health and Systemic Diseases)
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Abstract

Objective: Investigate if there is an association between apical periodontitis and diabetes mellitus. Material and methods: A bibliographic search was performed on Medline/PubMed, Scopus and Cochrane databases using the keywords apical periodontitis and diabetes mellitus. Published papers written in English and performed on animals or humans were included. Meta-analysis was performed using the OpenMeta (analyst) tool for the statistical analysis. The variables analyzed were the prevalence of Apical Periodontitis (AP) among teeth and patients with Diabetes Mellitus (DM). Results: Of the total studies found, only 21 met the inclusion criteria. Ten clinical studies on animals, ten studies on humans and a systematic review were included. Meta-analysis shows that the prevalence of teeth with apical periodontitis among patients with diabetes mellitus has an odds ratio of 1.166 corresponding to 507 teeth with AP + DM and 534 teeth with AP without DM. The prevalence of patients with AP and DM shows an odds ratio of 1.552 where 91 patients had AP + DM and 582 patients AP without DM. Conclusion: Scientific evidence suggests that there could be a common physiopathological factor between apical periodontitis and diabetes mellitus but more prospective studies are needed to investigate the association between these two diseases.
Keywords: apical periodontitis; diabetes mellitus; glycated haemoglobin; HbA1c; prevalence apical periodontitis; diabetes mellitus; glycated haemoglobin; HbA1c; prevalence

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MDPI and ACS Style

Pérez-Losada, F.d.L.; Estrugo-Devesa, A.; Castellanos-Cosano, L.; Segura-Egea, J.J.; López-López, J.; Velasco-Ortega, E. Apical Periodontitis and Diabetes Mellitus Type 2: A Systematic Review and Meta-Analysis. J. Clin. Med. 2020, 9, 540. https://doi.org/10.3390/jcm9020540

AMA Style

Pérez-Losada FdL, Estrugo-Devesa A, Castellanos-Cosano L, Segura-Egea JJ, López-López J, Velasco-Ortega E. Apical Periodontitis and Diabetes Mellitus Type 2: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 2020; 9(2):540. https://doi.org/10.3390/jcm9020540

Chicago/Turabian Style

Pérez-Losada, Flor de Liz, Albert Estrugo-Devesa, Lissett Castellanos-Cosano, Juan José Segura-Egea, José López-López, and Eugenio Velasco-Ortega. 2020. "Apical Periodontitis and Diabetes Mellitus Type 2: A Systematic Review and Meta-Analysis" Journal of Clinical Medicine 9, no. 2: 540. https://doi.org/10.3390/jcm9020540

APA Style

Pérez-Losada, F. d. L., Estrugo-Devesa, A., Castellanos-Cosano, L., Segura-Egea, J. J., López-López, J., & Velasco-Ortega, E. (2020). Apical Periodontitis and Diabetes Mellitus Type 2: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine, 9(2), 540. https://doi.org/10.3390/jcm9020540

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